Evidence map›Paper›PMID 30473096›Full record

Trial reportMolecular metabolism2018

Phenotyping of circulating extracellular vesicles (EVs) in obesity identifies large EVs as functional conveyors of Macrophage Migration Inhibitory Factor.

Jérémy Amosse, Maëva Durcin, Marine Malloci, Luisa Vergori, Audrey Fleury, Frédéric Gagnadoux, Séverine Dubois, Gilles Simard, Jérôme Boursier, Olivier Hue and 3 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
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  6. Adipose-Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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  15. Extracellular Vesicles and Obesity.Advances in experimental medicine and biology · 2023
    Review
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jérémy AmosseINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France.
Maëva DurcinINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France; Adaptation to Tropical Climate and Exercise Laboratory, EA3596, University of the French West Indies, Pointe-à-Pitre, Guadeloupe, France.
Marine MallociINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France.
Luisa VergoriINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France.
Audrey FleuryINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France.
Frédéric GagnadouxINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France; Centre Hospitalo-Universitaire d'Angers, Angers, France.
Séverine DuboisINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France; Centre Hospitalo-Universitaire d'Angers, Angers, France.
Gilles SimardINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France; Centre Hospitalo-Universitaire d'Angers, Angers, France.
Jérôme BoursierCentre Hospitalo-Universitaire d'Angers, Angers, France; HIFIH, EA3859, Université d'Angers, Angers, France.
Olivier HueAdaptation to Tropical Climate and Exercise Laboratory, EA3596, University of the French West Indies, Pointe-à-Pitre, Guadeloupe, France.
M Carmen MartinezINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France.
Ramaroson AndriantsitohainaINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France.
Soazig Le LayINSERM U1063, Oxidative Stress and Metabolic Pathologies, Angers University, France. Electronic address: soazig.lelay@inserm.fr.
Inserm · FRCentre Hospitalier Universitaire d'Angers · FRUniversité des Antilles · GP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveObesity-associated metabolic dysfunctions are linked to dysregulated production of adipokines. Accumulating evidence suggests a role for fat-derived extracellular vesicles (EVs) in obesity-metabolic disturbances. Since EVs convey numerous proteins we aimed to evaluate their contribution in adipokine secretion.

methodsPlasma collected from metabolic syndrome patients were used to isolate EV subtypes, namely microvesicles (MVs) and exosomes (EXOs). Numerous soluble factor concentrations were measured successively on total, MV- and EXO-depleted plasma by multiplexed immunoassays.

resultsCirculating MVs and EXOs were significantly increased with BMI, supporting a role of EVs as metabolic relays in obesity. Obesity was associated with dysregulated soluble factor production. Sequential depletion of plasma MVs and EXOs did not modify plasma levels of these molecules, with the exception of Macrophage Migration Inhibitory Factor (MIF). Half of plasma MIF circulated within MVs, and this MV secretory pathway was conserved over different MIF-producing cells. Although MV-associated MIF triggered rapid ERK1/2 activation in macrophages, these functional MV-MIF effects specifically relied on MIF tautomerase activity.

conclusionOur results emphasize the importance of reconsidering MIF-metabolic actions with regard to its MV-associated form and opening new EV-based strategies for therapeutic MIF approaches.

Indexed as

AnimalsCell-Derived MicroparticlesCells, CulturedExosomesFemaleHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMacrophagesMaleMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3ObesityRAW 264.7 CellsSecretory PathwayIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3AdipokinesExosomesExtracellular vesiclesMicrovesiclesMIFObesity

Identifiers

PMID30473096
PMCPMC6309717
OpenAlexW2897243078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.