Trial reportThe Journal of pediatrics2018
Effects of Delayed Cord Clamping on 4-Month Ferritin Levels, Brain Myelin Content, and Neurodevelopment: A Randomized Controlled Trial.
Trial report in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Placental Transfusion on Early Brain Development
Effects of Placental Transfusion on Early Brain Development in Infants Born at Term: Follow-Up at 3 & 4 Years of Age
Donor Breast Milk and Serum Ferritin Levels in Very Preterm Infants: A Prospective, Observational Study
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation.Clinical and experimental emergency medicine · 2026Guideline
- Umbilical cord milking and delayed cord clamping for the prevention of neonatal hypoglycaemia: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Umbilical cord milking versus delayed cord clamping in term infants: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2021Pooled it
- Does Delayed Cord Clamping Improve Long-Term (≥4 Months) Neurodevelopment in Term Babies? A Systematic Review and a Meta-Analysis of Randomized Clinical Trials.Frontiers in pediatrics · 2021Pooled it
- Neurobehavioral Outcomes at 10 Years of Age following Delayed Umbilical Cord Clamping: A Follow-Up Study after a Randomized Trial.Neonatology · 2025Trial
- Early or delayed cord clamping during transition of term newborns: does it make any difference in cerebral tissue oxygenation?Italian journal of pediatrics · 2024Trial
- Cut umbilical cord milking (C-UCM) as a mode of placental transfusion in non-vigorous preterm neonates: a randomized controlled trial.European journal of pediatrics · 2023Trial
- Effects of delayed cord clamping at different time intervals in late preterm and term neonates: a randomized controlled trial.European journal of pediatrics · 2023Trial
- Delayed versus early umbilical cord clamping for near-term infants born to preeclamptic mothers; a randomized controlled trial.BMC pregnancy and childbirth · 2022Trial
- The Effects of Delayed Cord Clamping on 12-Month Brain Myelin Content and Neurodevelopment: A Randomized Controlled Trial.American journal of perinatology · 2022Trial
- [Effect of delayed cord clamping and umbilical cord milking on cerebral hemodynamics in preterm infants: a randomized double-blind controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Trial
- Effect of Delayed Cord Clamping on Neurodevelopment at 3 Years: A Randomized Controlled Trial.Neonatology · 2021Trial
- From knowledge to action: understanding midwives' challenges in implementing delayed cord clamping in Northern Ghana.Maternal health, neonatology and perinatology · 2026Article
- Proanthocyanidin B2 Alleviates Cuprizone-Induced Demyelination by Regulating the Astrocytic xCT/GSH/GPX4 Axis.CNS neuroscience & therapeutics · 2025Article
- Extra-uterine placental transfusion and intact-cord stabilisation of infants in caesarean sections: an intervention development and pilot-study (INTACT-1).BMC pregnancy and childbirth · 2025Article
- Impact of the Timing of Umbilical Cord Clamping on Maternal and Neonatal Outcomes in Saudi Arabia.Cureus · 2024Article
- Effects of timing of umbilical cord clamping for mother and newborn: a narrative review.Archives of gynecology and obstetrics · 2024Review
- Anemia, Iron Supplementation, and the Brain.Clinics in perinatology · 2023Review
- Human white matter myelinates faster in utero than ex utero.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cord management in non-vigorous newborns.Seminars in perinatology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate whether placental transfusion influences brain myelination at 4 months of age. STUDY
designA partially blinded, randomized controlled trial was conducted at a level III maternity hospital in the US. Seventy-three healthy term pregnant women and their singleton fetuses were randomized to either delayed umbilical cord clamping (DCC, >5 minutes) or immediate clamping (ICC, <20 seconds). At 4 months of age, blood was drawn for ferritin levels. Neurodevelopmental testing (Mullen Scales of Early Learning) was administered, and brain myelin content was measured with magnetic resonance imaging. Correlations between myelin content and ferritin levels and group-wise DCC vs ICC brain myelin content were completed.
resultsIn the DCC and ICC groups, clamping time was 172 ± 188 seconds vs 28 ± 76 seconds (P < .002), respectively; the 48-hour hematocrit was 57.6% vs 53.1% (P < .01). At 4 months, infants with DCC had significantly greater ferritin levels (96.4 vs 65.3 ng/dL, P = .03). There was a positive relationship between ferritin and myelin content. Infants randomized to the DCC group had greater myelin content in the internal capsule and other early maturing brain regions associated with motor, visual, and sensory processing/function. No differences were seen between groups in the Mullen testing.
conclusionAt 4 months, infants born at term receiving DCC had greater ferritin levels and increased brain myelin in areas important for early life functional development. Endowment of iron-rich red blood cells obtained through DCC may offer a longitudinal advantage for early white matter development.
trial registrationClinicalTrials.gov: NCT01620008.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.