Evidence map›Paper›PMID 30473005›Full record

ReviewAdvances in biological regulation2018

Sphingolipids in adipose tissue: What's tipping the scale?

Johana M Lambert, Andrea K Anderson, L Ashley Cowart

Open access · greenAbstract readReview
In one paragraph

Review in Advances in biological regulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Nervonic acid limits weight gain in a mouse model of diet-induced obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Johana M LambertDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Andrea K AndersonDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
L Ashley CowartDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA; Hunter Holmes McGuire Veteran's Affairs Medical Center, Richmond, VA, USA. Electronic address: lauren.cowart@vcuhealth.org.
Hunter Holmes McGuire VA Medical Center · USMedical University of South Carolina · USVirginia Commonwealth University · US

Funding

Sphingolipids in Diabetic CardiomyopathyR01HL117233 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI COWART, LAUREN ASHLEY · 2014 to 2018
$1.9M
Sphingolipids in the Pathophysiology of Obesity and DiabetesI01BX000200 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI COWART, LAUREN ASHLEY · 2009 to 2025
–
BLRD VA I01 BX000200NHLBI NIH HHS R01 HL117233
6 · The paper itself

Abstract

Adipose tissue lies at the heart of obesity, mediating its many effects upon the rest of the body, with its unique capacity to expand and regenerate, throughout the lifespan of the organism. Adipose is appreciated as an endocrine organ, with its myriad adipokines that elicit both physiological and pathological outcomes. Sphingolipids, bioactive signaling molecules, affect many aspects of obesity and the metabolic syndrome. While sphingolipids are appreciated in the context of these diseases in other tissues, there are many discoveries yet to be uncovered in the adipose tissue. This review focuses on the effects of sphingolipids on various aspects of adipose function and dysfunction. The processes of adipogenesis, metabolism and thermogenesis, in addition to inflammation and insulin resistance are intimately linked to sphingolipids as discussed below.

Indexed as

AdipokinesAdipose TissueAnimalsHumansObesitySphingolipidsAdipokinesSphingolipidsAdipogenesisInflammationInsulin resistanceObesitySphingolipid synthesis

Identifiers

PMID30473005
PMCPMC11129658
OpenAlexW2896157557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.