ArticleDevelopmental cell2018
Cell Cycle Heterogeneity Can Generate Robust Cell Type Proportioning.
Article in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Article
- Mitigating Cell Cycle Effects in Multi-Omics Data: Solutions and Analytical Frameworks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- AI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis.PLoS computational biology · 2024Article
- mTORC1 pathway activity biases cell fate choice.Scientific reports · 2024Article
- Ion Signaling in Cell Motility and Development inBiomolecules · 2024Review
- Cell-cell heterogeneity in phosphoenolpyruvate carboxylase biases early cell fate priming inFrontiers in cell and developmental biology · 2024Article
- Collective effects of cell cleavage dynamics.Frontiers in cell and developmental biology · 2024Review
- Article
- Nodal signaling establishes a competency window for stochastic cell fate switching.Developmental cell · 2022Article
- Article
- The regulation of totipotency transcription: Perspective fromFrontiers in cell and developmental biology · 2022Review
- Article
- Cell cycle heterogeneity directs spontaneous 2C state entry and exit in mouse embryonic stem cells.Stem cell reports · 2021Article
- Imaging developmental cell cycles.Biophysical journal · 2021Review
- Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology.BMC biology · 2021Article
- Evolution of Reproductive Division of Labor - Lessons Learned From the Social AmoebaFrontiers in cell and developmental biology · 2021Article
- Possible Involvement of the Nutrient and Energy Sensors mTORC1 and AMPK in Cell Fate Diversification in a Non-Metazoan Organism.Frontiers in cell and developmental biology · 2021Article
- Coordination between patterning and morphogenesis ensures robustness during mouse development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Article
- WildEcology and evolution · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Cell-cell heterogeneity can facilitate lineage choice during embryonic development because it primes cells to respond to differentiation cues. However, remarkably little is known about the origin of heterogeneity or whether intrinsic and extrinsic variation can be controlled to generate reproducible cell type proportioning seen in vivo. Here, we use experimentation and modeling in D. discoideum to demonstrate that population-level cell cycle heterogeneity can be optimized to generate robust cell fate proportioning. First, cell cycle position is quantitatively linked to responsiveness to differentiation-inducing signals. Second, intrinsic variation in cell cycle length ensures cells are randomly distributed throughout the cell cycle at the onset of multicellular development. Finally, extrinsic perturbation of optimal cell cycle heterogeneity is buffered by compensatory changes in global signal responsiveness. These studies thus illustrate key regulatory principles underlying cell-cell heterogeneity optimization and the generation of robust and reproducible fate choice in development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.