Trial reportGut2019
Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons.
Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Gut, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02425774 (Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway), which is not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway: A Potential New Therapeutical Intervention for Postoperative Ileus
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Use of Acetylcholinesterase Inhibitors in Reducing Time to Gastrointestinal Function Recovery following Abdominal Surgery: A Systematic Review.Digestive surgery · 2024Pooled it
- The potential for autonomic neuromodulation to reduce perioperative complications and pain: a systematic review and meta-analysis.British journal of anaesthesia · 2022Pooled it
- Effects of prucalopride succinate on postoperative bowel motility and inflammation following minimally invasive gastrectomy.Scientific reports · 2026Trial
- Integrated metabolomic insights into the mechanism ofFrontiers in immunology · 2025Trial
- Impact of intravenous dexmedetomidine on gastrointestinal function recovery after laparoscopic hysteromyomectomy: a randomized clinical trial.Scientific reports · 2022Trial
- Effect of prucalopride to improve time to gut function recovery following elective colorectal surgery: randomized clinical trial.The British journal of surgery · 2022Trial
- P2X7R+CD8αβiScience · 2026Article
- Dup15q model mice exhibit impaired gastrointestinal motility and a constipation-like phenotype, alleviated by prucalopride.Translational psychiatry · 2026Article
- Enteric neuro-immune-tumor ecosystem in pancreatic, colorectal, and gastric malignancies: context dependence and translational priorities.Frontiers in immunology · 2026Review
- Electroacupuncture Attenuates Colitis in Mice Through Activation of Vagus Cholinergic Antiinflammatory Pathways.Journal of inflammation research · 2026Article
- Glial Connexin-43 Is a Pathogenic Mechanism Promoting Gut Inflammation in Postoperative Ileus Induced by Gut Surgical Manipulation With Potential Relevance to Humans.Cellular and molecular gastroenterology and hepatology · 2026Article
- Modeling Postoperative Pathologic Ileus in Mice: A Simplified and Translational Approach.Neurogastroenterology and motility · 2025Article
- Supplementing HIV-ART with cannabinoids increases serotonin, BHB, and Ahr signaling while reducing secondary bile acids and acylcholines.Science advances · 2025Article
- Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury.Neural regeneration research · 2025Article
- Combinatorial targeting of NMDARs and 5-HTAlzheimer's research & therapy · 2025Article
- Gut sensory neurons as regulators of neuro-immune-microbial interactions: from molecular mechanisms to precision therapy for IBD/IBS.Journal of neuroinflammation · 2025Review
- Intestinal neuron-associated macrophages in health and disease.Nature immunology · 2025Review
- Neuroimmune Interactions in Pancreatic Cancer.Biomedicines · 2025Review
- Pharmacologic treatments for gastroparesis.Pharmacological reviews · 2025Review
- The Modulation of Neuroimmune Responses in Peripheral Inflammation.Journal of inflammation research · 2025Review
Corrections and comments
- Commented on by
Authors and funding
28 authors at 3 institutions in 2 countries.
Nathalie Stakenborg *Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.ORCID 0000-0002-6229-0045
Evelien Labeeuw *Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Pedro J Gomez-Pinilla *Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Sebastiaan De SchepperDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Raymond AertsDepartment of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium.
Gera GoverseDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium.
Giovanna FarroDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Iris AppeltansDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Elisa MeroniDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Michelle StakenborgDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium.
Maria Francesca ViolaDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Erika Gonzalez-DominguezDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Goele BosmansDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Yeranddy A AlpizarDepartment of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven; VIB Center for Brain & Disease Research, Leuven, Belgium.
Albert WolthuisDepartment of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium.
Andre D'HooreDepartment of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium.
Kim Van BeekDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Simon VerheijdenDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Marleen VerhaegenDepartment of Anesthesiology, University Hospital of Leuven, Leuven, Belgium.
Rita DeruaDepartment of Cellular and Molecular Medicine, Laboratory of Protein Phosphorylation and Proteomics, Universitiy of Leuven, Leuven, Belgium.
Etienne WaelkensDepartment of Cellular and Molecular Medicine, Laboratory of Protein Phosphorylation and Proteomics, Universitiy of Leuven, Leuven, Belgium.
Milena MorettiCNR, Neuroscience Institute-Milano, Biometra University of Milan, Milan, Italy.
Cecilia GottiCNR, Neuroscience Institute-Milano, Biometra University of Milan, Milan, Italy.
Patrick AugustijnsDepartment of Pharmaceutical and Pharmacological Sciences, Laboratory for Drug Delivery and Disposition, University of Leuven, Leuven, Belgium.
Karel TalaveraDepartment of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven; VIB Center for Brain & Disease Research, Leuven, Belgium.
Pieter Vanden BergheDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Enteric Neuroscience, University of Leuven, Leuven, Belgium.
Gianluca Matteoli *Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium.
Guy E Boeckxstaens *Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
KU Leuven · BEUniversity of Milan · ITVIB-KU Leuven Center for Brain & Disease Research · BE
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesVagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive
designUsing Ca
resultsEFS reduced the ATP-induced Ca
conclusionEnteric neurons dampen mMφ activation, an effect mimicked by prucalopride. Preoperative, but not postoperative treatment with prucalopride prevents intestinal inflammation and shortens POI in both mice and human, indicating that preoperative administration of 5-HT4R agonists should be further evaluated as a treatment of POI. TRIAL REGISTRATION NUMBER: NCT02425774.
Indexed as
BenzofuransIleusIntestine, SmallMuscle, SmoothPostoperative ComplicationsAdultalpha7 Nicotinic Acetylcholine ReceptorAnimalsDisease Models, AnimalFemaleGastrointestinal MotilityHumansInflammationMacrophagesMaleMicealpha7 Nicotinic Acetylcholine ReceptorBenzofuransprucaloprideSerotonin 5-HT4 Receptor Agonistsanti-inflammatoryenteric neuronileusMacrophagesprucalopride
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT02425774ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.