ArticleArchives of disease in childhood. Fetal and neonatal edition2019
Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicentre Clinical Evaluation of a Decision Support Algorithm for Neonatal Seizure Detection
A Multicenter Diagnostic Study on the Utility of AI-assisted Continue EEG Diagnosis of Neonatal Seizures
AI-assisted cEEG Diagnosis of Neonatal Seizures to Optimize the Administration of Antiseizure Medication: a Multicenter, Randomised, Controlled Trial
Who cites it
35 citing papers in PubMed, 81 citations in OpenAlex.
- Temporal evolution of electrographic seizures in newborn infants with hypoxic-ischaemic encephalopathy requiring therapeutic hypothermia: a secondary analysis of the ANSeR studies.The Lancet. Child & adolescent health · 2024Trial
- Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates: A Randomized Clinical Trial.JAMA network open · 2021Trial
- A machine-learning algorithm for neonatal seizure recognition: a multicentre, randomised, controlled trial.The Lancet. Child & adolescent health · 2020Trial
- AES ILAE North America Symposium: Guiding Evidence-Based Epilepsy Management.Epilepsy currents · 2026Article
- Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures.Epilepsia open · 2025Observational
- Defining neonatal status epilepticus: A scoping review from the ILAE neonatal task force.Epilepsia open · 2025Article
- Observational
- Scaling convolutional neural networks achieves expert level seizure detection in neonatal EEG.NPJ digital medicine · 2025Article
- Continuous video recording with simultaneous amplitude-integrated EEG monitoring to improve seizure recognition in newborns.Frontiers in pediatrics · 2025Article
- Electrographic monitoring for seizure detection in the neonatal unit: current status and future direction.Pediatric research · 2024Review
- Pharmacokinetics and safety of brivaracetam in neonates with repeated electroencephalographic seizures: A multicenter, open-label, single-arm study.Epilepsia open · 2024Article
- Deep Learning for Generalized EEG Seizure Detection after Hypoxia-Ischemia-Preclinical Validation.Bioengineering (Basel, Switzerland) · 2024Article
- Questions and Controversies in Neonatal Seizures.Children (Basel, Switzerland) · 2023Review
- Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units.JAMA network open · 2023Article
- Variations in care of neonates during therapeutic hypothermia: call for care practice bundle implementation.Pediatric research · 2023Article
- Continuous electroencephalography in the intensive care unit: A critical review and position statement from an Australian and New Zealand perspective.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023Article
- Effect of neonatal seizure burden and etiology on the long-term outcome: data from a randomized, controlled trial.Annals of the Child Neurology Society · 2023Article
- Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.Epilepsia · 2023Article
- Why monitor the neonatal brain-that is the important question.Pediatric research · 2023Article
- Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 4 countries.
Funding
Abstract
objectiveThe aim of this multicentre study was to describe detailed characteristics of electrographic seizures in a cohort of neonates monitored with multichannel continuous electroencephalography (cEEG) in 6 European centres.
methodsNeonates of at least 36 weeks of gestation who required cEEG monitoring for clinical concerns were eligible, and were enrolled prospectively over 2 years from June 2013. Additional retrospective data were available from two centres for January 2011 to February 2014. Clinical data and EEGs were reviewed by expert neurophysiologists through a central server.
resultsOf 214 neonates who had recordings suitable for analysis, EEG seizures were confirmed in 75 (35%). The most common cause was hypoxic-ischaemic encephalopathy (44/75, 59%), followed by metabolic/genetic disorders (16/75, 21%) and stroke (10/75, 13%). The median number of seizures was 24 (IQR 9-51), and the median maximum hourly seizure burden in minutes per hour (MSB) was 21 min (IQR 11-32), with 21 (28%) having status epilepticus defined as MSB>30 min/hour. MSB developed later in neonates with a metabolic/genetic disorder. Over half (112/214, 52%) of the neonates were given at least one antiepileptic drug (AED) and both overtreatment and undertreatment was evident. When EEG monitoring was ongoing, 27 neonates (19%) with no electrographic seizures received AEDs. Fourteen neonates (19%) who did have electrographic seizures during cEEG monitoring did not receive an AED.
conclusionsOur results show that even with access to cEEG monitoring, neonatal seizures are frequent, difficult to recognise and difficult to treat. OBERSERVATION STUDY NUMBER: NCT02160171.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.