Evidence map›Paper›PMID 30472604›Full record

ArticleEuropean journal of medicinal chemistry2019

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca

Jatinder Kaur, Monica Soto-Velasquez, Zhong Ding, Ahmadreza Ghanbarpour, Markus A Lill, Richard M van Rijn, Val J Watts, Daniel P Flaherty

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Action potential-independent spontaneous microdomain CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Mechanistic Studies andJournal of medicinal chemistry · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. CaFrontiers in pharmacology · 2022
    Review
  14. Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives.International journal of molecular sciences · 2021
    Review
  15. Article
  16. International journal of molecular sciences · 2021
    Article
  17. Article
  18. Ultrapotent Inhibitor ofJournal of medicinal chemistry · 2020
    Article
  19. CaMolecular pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jatinder KaurDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr, West Lafayette, IN, 47907, USA.
Monica Soto-VelasquezDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr, West Lafayette, IN, 47907, USA.
Zhong DingDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr, West Lafayette, IN, 47907, USA.
Ahmadreza GhanbarpourDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr, West Lafayette, IN, 47907, USA.
Markus A LillDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr, West Lafayette, IN, 47907, USA; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA.
Richard M van RijnDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr, West Lafayette, IN, 47907, USA; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA.
Val J WattsDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr, West Lafayette, IN, 47907, USA; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA.
Daniel P FlahertyDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr, West Lafayette, IN, 47907, USA; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: dflaher@purdue.edu.
Purdue University West Lafayette · US

Funding

Understanding adaptive signaling of neuronal adenyly cyclases using siRNAR33MH101673 · NIMH · PURDUE UNIVERSITY · PI WATTS, VAL J · 2015 to 2016
$889k
Understanding adaptive signaling of neuronal adenyly cyclases using siRNAR21MH101673 · NIMH · PURDUE UNIVERSITY · PI WATTS, VAL J · 2014 to 2014
$261k
NIMH NIH HHS R21 MH101673NIMH NIH HHS R33 MH101673
6 · The paper itself

Abstract

Adenylyl cyclases type 1 (AC1) and 8 (AC8) are group 1 transmembrane adenylyl cyclases (AC) that are stimulated by Ca

Indexed as

Adenylyl Cyclase InhibitorsAdenylyl CyclasesAnalgesicsAnimalsBinding SitesCalciumCalmodulinChronic PainCyclic AMPInflammationMiceOxadiazoles1,3,4-oxadiazoleAdenylyl Cyclase InhibitorsAdenylyl CyclasesAnalgesicsCalciumCalmodulinCyclic AMPOxadiazoles1,3,4-OxadiazoleAdenylyl cyclase inhibitorsChronic pain treatmentMolecular modeling

Identifiers

PMID30472604
PMCPMC6310635
OpenAlexW2901716464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.