ArticleGeneral and comparative endocrinology2019
Involvement of epigenetic modifications in thyroid hormone-dependent formation of adult intestinal stem cells during amphibian metamorphosis.
Article in General and comparative endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- RePo index: a multidimensional framework to quantify genetic resilience in data-limited amphibian faunas.BMC genomics · 2026Article
- Effects of hormones on intestinal stem cells.Stem cell research & therapy · 2023Review
- Liver development duringiScience · 2023Article
- Article
- Thyroid hormone signaling in the intestinal stem cells and their niche.Cellular and molecular life sciences : CMLS · 2022Review
- A Role of Endogenous Histone Acetyltransferase Steroid Hormone Receptor Coactivator 3 in Thyroid Hormone Signaling DuringThyroid : official journal of the American Thyroid Association · 2021Article
- Remarkable metabolic reorganization and altered metabolic requirements in frog metamorphic climax.Frontiers in zoology · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
Amphibian metamorphosis has long been used as model to study postembryonic development in vertebrates, a period around birth in mammals when many organs/tissues mature into their adult forms and is characterized by peak levels of plasma thyroid hormone (T3). Of particular interest is the remodeling of the intestine during metamorphosis. In the highly-related anurans Xenopus laevis and Xenopus tropicalis, this remodeling process involves larval epithelial cell death and de novo formation of adult stem cells via dedifferentiation of some larval cells under the induction of T3, making it a valuable system to investigate how adult organ-specific stem cells are formed during vertebrate development. Here, we will review some studies by us and others on how T3 regulates the formation of the intestinal stem cells during metamorphosis. We will highlight the involvement of nucleosome removal and a positive feedback mechanism involving the histone methyltransferases in gene regulation by T3 receptor (TR) during this process.
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Registered trials
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