ArticleJournal of pain and symptom management2019
Pretreatment Psychoneurological Symptoms and Their Association With Longitudinal Cognitive Function and Quality of Life in Older Breast Cancer Survivors.
Article in Journal of pain and symptom management, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- Trial
- Web-Based Cognitive Rehabilitation for Patients With Aggressive Lymphoma With Perceived Cognitive Impairment: A Randomised Pilot Study.Psycho-oncology · 2026Trial
- Pilot Study of Oral Microbiome and Psychoneurological Symptom Cluster in Breast Cancer.Nursing research · 2026Article
- The chain-mediating role of anxiety and depression in the relationship between symptom clusters and perceived cognitive function in nasopharyngeal carcinoma survivors: a cross-sectional study of 556 participants.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Symptom Clusters and Symptom Burden in Cancer Survivors.Cancer medicine · 2026Article
- Survivorship Issues in Older Adults with Breast Cancer.Current breast cancer reports · 2025Article
- Pain and Cognitive Concerns Among Breast Cancer Survivors: The Mediating Role of Substance Use Coping.Cancer medicine · 2025Article
- Profiling of psychoneurological symptoms in newly diagnosed head and neck cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Application of comprehensive geriatric assessment in oncology nursing: A literature review on optimizing treatment decisions and patient outcomes.World journal of clinical oncology · 2025Review
- Natural trajectory subclasses of cognitive impairment in breast cancer patients experiencing insomnia.Cancer · 2025Article
- Predictive risk model of mild cognitive impairment in patients with malignant haematological diseases after haematopoietic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Network Analyses Applied to the Dimensions of Cancer-Related Fatigue in Women With Breast Cancer.Cancer medicine · 2024Article
- Association between Cognitive Function and Physical Function, Frailty, and Quality of Life in Older Breast Cancer Survivors.Cancers · 2024Article
- Article
- Latent class symptom profiles of colorectal cancer survivors with cancer-related cognitive impairment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Associations of inflammation with neuropsychological symptom cluster in patients with Head and neck cancer: A longitudinal study.Brain, behavior, & immunity - health · 2023Article
- The Cancer Genomic Integration Model for Symptom Science (CGIMSS): A Biopsychosocial Framework.Biological research for nursing · 2023Review
- Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review.Western journal of nursing research · 2023Article
- Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment.Frontiers in medicine · 2023Review
- Longitudinal evaluation of dehydroepiandrosterone (DHEA), its sulfated form and estradiol with cancer-related cognitive impairment in early-stage breast cancer patients receiving chemotherapy.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
23 authors at 10 institutions in 1 country.
Funding
Abstract
contextSymptoms affect quality of life (QOL), functional status, and cognitive function in cancer survivors, but older survivors are understudied.
objectivesThe objectives of this study were to identify prototypical presystemic therapy psychoneurological symptom clusters among older breast cancer survivors and determine whether these symptom clusters predicted cognition and QOL over time.
methodsWomen with newly diagnosed nonmetastatic breast cancer (n = 319) and matched noncancer controls (n = 347) aged 60+ years completed questionnaires and neuropsychological tests before systemic therapy and 12 and 24 months later. Latent class analysis identified clusters of survivors based on their pretherapy depression, anxiety, fatigue, sleep disturbance, and pain. Linear mixed-effects models examined changes in objective cognition, perceived cognition, and functional status (Instrumental Activities of Daily Living disability, functional well-being, and breast cancer-specific QOL) by group, controlling for covariates.
resultsNearly one-fifth of older survivors were classified as having high pretherapy symptoms (n = 51; 16%); the remainder had low symptoms (n = 268; 84%); both groups improved over time on all outcomes. However, compared to the low symptom group and controls, survivors with high symptoms had lower baseline objective cognition and lower perceived cognition at baseline and 24 months, lower functional well-being at baseline and 12 months, greater Instrumental Activities of Daily Living disability at baseline, and lower breast cancer-specific QOL at all time points (all P < 0.05).
conclusionNearly one-fifth of older breast cancer survivors had high psychoneurological symptoms at diagnosis, which predicted clinically meaningful decrements in perceived cognition and function in the first 24 months after diagnosis. Pretreatment psychoneurological symptom clusters could identify survivors for monitoring or intervention.
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