Evidence map›Paper›PMID 30471965›Full record

ArticleBrazilian journal of physical therapy

EMG breakthrough during cortical silent period in congenital hemiparesis: a descriptive case series.

Maíra C Lixandrão, James W Stinear, Tonya Rich, Chao-Ying Chen, Tim Feyma, Gregg D Meekins, Bernadette T Gillick

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of physical therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02250092 (Synergistic Effect of Combined Transcranial Direct Current Stimulation/Constraint Induced Movement Therapy in Children With Hemiparesis), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02250092 nacompletednot on this map

Synergistic Effect of Combined Transcranial Direct Current Stimulation/Constraint Induced Movement Therapy in Children With Hemiparesis

TypeinterventionalSponsorUniversity of MinnesotaRan2014 to 2017Enrolled20ConditionsPediatric HemiparesisArmsTranscranial Direct Current Stimulation (tDCS), Placebo Comparator
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Maíra C LixandrãoDivision of Rehabilitation Science, Medical School, University of Minnesota, Minneapolis, MN, United States; Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil.
James W StinearNew Zealand Movement Neuroscience Laboratory, Department of Exercise Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
Tonya RichDivision of Rehabilitation Science, Medical School, University of Minnesota, Minneapolis, MN, United States.
Chao-Ying ChenDivision of Rehabilitation Science, Medical School, University of Minnesota, Minneapolis, MN, United States.
Tim FeymaGillette Children's Specialty Healthcare, St. Paul, MN, United States.
Gregg D MeekinsDepartment of Neurology, Medical School, University of Minnesota, Minneapolis, MN, United States.
Bernadette T GillickDivision of Rehabilitation Science, Medical School, University of Minnesota, Minneapolis, MN, United States. Electronic address: gillick@umn.edu.
University of Minnesota Medical Center · USGillette Children's Specialty Healthcare · USUniversity of Auckland · NZ

Funding

Novel Neuromodulatory Intervention in the Rehabilitation of Pediatric HemiparesisK01HD078484 · NICHD · UNIVERSITY OF MINNESOTA · PI GILLICK, BERNADETTE THERESE · 2014 to 2018
$654k
NICHD NIH HHS K01 HD078484
6 · The paper itself

Abstract

backgroundThe cortical silent period is a transient suppression of electromyographic activity after a transcranial magnetic stimulation pulse, attributed to spinal and supraspinal inhibitory mechanisms. Electromyographic breakthrough activity has been observed in healthy adults as a result of a spinal reflex response within the cortical silent period.

objectivesThe objective of this case series is to report the ipsilesional and contralesional cortical silent period and the electromyographic breakthrough activity of 7 children with congenital hemiparesis.

methodsTMS was delivered over the ipsilesional and contralesional primary motor cortices with resting motor threshold and cortical silent period measures recorded from first dorsal interosseous muscle.

resultsSeven children (13±2 years) were included. Ipsilesional and contralesional resting motor thresholds ranged from 49 to 80% and from 38 to 63% of maximum stimulator output, respectively. Ipsilesional (n=4) and contralesional (n=7) cortical silent period duration ranged from 49 to 206ms and 81 to 150ms, respectively. Electromyographic breakthrough activity was observed ipsilesionally in 3/4 (75%) and contralesionally in 3/7 (42.8%) participants. In the 3 children with ipsilesional breakthrough activity during the cortical silent period, all testing trials showed breakthrough. Contralesional breakthrough activity was observed in only one of the analyzable trials in each of those 3 participants. The mean peak amplitude of breakthrough activity ranged from 45 to 214μV (ipsilesional) and from 23 to 93μV (contralesional).

conclusionFurther research is warranted to understand the mechanisms and significance of electromyographic breakthrough activity within the cortical silent period in congenital hemiparesis. Understanding these mechanisms may lead to the design of tailored neuromodulation interventions for physical rehabilitation.

trial registrationNCT02250092 (https://clinicaltrials.gov/ct2/show/NCT02250092).

Indexed as

AdultChildElectromyographyHumansMotor CortexMuscle, SkeletalParesisRestTranscranial Magnetic StimulationCerebral palsyCortical inhibitionElectromyographyRehabilitationSpinal reflex

Identifiers

PMID30471965
PMCPMC6994318
OpenAlexW2900879071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.