ArticleJournal of the neurological sciences2019
Estimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension.
Article in Journal of the neurological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Prevalence of nephropathy among patients with diabetes mellitus in Africa: a systematic review and meta-analysis.Frontiers in clinical diabetes and healthcare · 2025Pooled it
- A Systematic Review of the Burden of Stroke in Ghana.BioMed research international · 2024Pooled it
- Stroke burden and associated predictors in Ghana: a Bayesian analysis of the WHO study on global ageing and adult health.Aging clinical and experimental research · 2026Article
- Incidence and predictors of stroke among hypertension patients in Awi Zone public hospitals, Northwest Ethiopia: Retrospective follow-up study.BMC cardiovascular disorders · 2026Article
- Association of estimated glomerular filtration rate with stroke risk in middle-aged and older Chinese adults: an integrated analysis of national and hospital cohorts.Environmental health and preventive medicine · 2026Article
- Determinants of visit-to-visit systolic blood pressure variability among Ghanaians with hypertension and diabetes mellitus.Ghana medical journal · 2023Article
- Predictors of rapid progression of estimated glomerular filtration rate among persons living with diabetes and/or hypertension in Ghana: Findings from a multicentre study.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Reduced Glomerular Filtration Rate and Risk of Stroke: A Nationwide Cohort Study in South Korea.Journal of atherosclerosis and thrombosis · 2021Article
- Antecedent febrile illness and occurrence of stroke in West Africa: The SIREN study.Journal of the neurological sciences · 2020Article
- Frequency & factors associated with apparent resistant hypertension among Ghanaians in a multicenter study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Frequency and factors linked to refractory hypertension among stroke survivors in Ghana.Journal of the neurological sciences · 2020Article
- Low blood pressure levels & incident stroke risk among elderly Ghanaians with hypertension.Journal of the neurological sciences · 2020Article
- Vascular-brain Injury Progression after Stroke (VIPS) study: concept for understanding racial and geographic determinants of cognitive decline after stroke.Journal of the neurological sciences · 2020Review
- Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans.Neurology · 2020Article
- Post-intervention qualitative assessment of mobile health technology to manage hypertension among Ghanaian stroke survivors.Journal of the neurological sciences · 2019Article
- Prevalence and predictors of chronic kidney disease among Ghanaian patients with hypertension and diabetes mellitus: A multicenter cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Evaluation of Vascular Event Risk while on Long-term Anti-retroviral Suppressive Therapy [EVERLAST]: Protocol for a prospective observational study.eNeurologicalSci · 2019Article
- Characteristics of hypertension among people living with HIV in Ghana: Impact of new hypertension guideline.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Burden of subclinical carotid atherosclerosis and vascular risk factors among people living with HIV in Ghana.Journal of the neurological sciences · 2019Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSub-Saharan Africa is currently experiencing a high burden of both chronic kidney disease (CKD) and stroke as a result of a rapid rise in shared common vascular risk factors such as hypertension and diabetes mellitus. However, no previous study has prospectively explored independent associations between CKD and incident stroke occurrence among indigenous Africans. This study sought to fill this knowledge gap.
methodsA prospective cohort study involving Ghanaians adults with hypertension or type II diabetes mellitus from 5 public hospitals. Patients were followed every 2 months in clinic for 18 months and assessed clinically for first ever stroke by physicians. Serum creatinine derived estimated glomerular filtration rates (eGFR) were determined at baseline for 2631 (81.7%) out of 3296 participants. We assessed associations between eGFR and incident stroke using a multivariate Cox Proportional Hazards regression model.
resultsStroke incidence rates (95% CI) increased with decreasing eGFR categories of 89, 60-88, 30-59 and <29 ml/min corresponding to incidence rates of 7.58 (3.58-13.51), 14.45 (9.07-21.92), 29.43 (15.95-50.04) and 66.23 (16.85-180.20)/1000 person-years respectively. Adjusted hazard ratios (95%CI) for stroke occurrence according to eGFR were 1.42 (0.63-3.21) for eGFR of 60-89 ml/min, 1.88 (1.17-3.02) for 30-59 ml/min and 1.52 (0.93-2.43) for <30 ml/min compared with eGFR of >89 ml/min. Adjusted HR for stroke occurrence among patients with hypertension with eGFR<60 ml/min was 3.69 (1.49-9.13), p = .0047 and among those with diabetes was 1.50 (0.56-3.98), p = .42.
conclusionCKD is dose-dependently associated with occurrence of incident strokes among Ghanaians with hypertension and diabetes mellitus. Further studies are warranted to explore interventions that could attenuate the risk of stroke attributable to renal disease among patients with hypertension in SSA.
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