Evidence map›Paper›PMID 30471556›Full record

ArticleAtherosclerosis2019

Greater progression of coronary artery calcification is associated with clinically relevant cognitive impairment in type 1 diabetes.

Jingchuan Guo, Karen A Nunley, Tina Costacou, Rachel G Miller, Caterina Rosano, Daniel Edmundowicz, Trevor J Orchard

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jingchuan GuoDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Karen A NunleyDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Tina CostacouDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Rachel G MillerDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Caterina RosanoDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Daniel EdmundowiczSection of Cardiology, Temple University Hospital, Philadelphia, PA, USA.
Trevor J OrchardDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: tjo@pitt.edu.
University of Pittsburgh · USTemple University Hospital · US

Funding

Epidemiology of Diabetes Complications (EDC) Phase II: renewalR37DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ORCHARD, TREVOR J. · 2009 to 2018
$6.5M
EPIDEMIOLOGY OF DIABETIC COMPLICATIONS--PHASE IIR01DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COSTACOU, TINA · 1986 to 2019
$5.6M
Imaging biomarkers of accelerated brain aging in Type-1 DiabetesR01DK089028 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSANO, CATERINA · 2010 to 2013
$2.3M
NIDDK NIH HHS R01 DK034818NIDDK NIH HHS R01 DK089028NIDDK NIH HHS R37 DK034818
6 · The paper itself

Abstract

BACKGROUND AND

aimsWe assessed the predictive role of coronary artery calcification (CAC) in clinically relevant cognitive impairment in 148 middle-aged individuals with childhood-onset type 1 diabetes (T1D) from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study.

methodsBaseline CAC was measured in 1996-98 and repeated 4-8 years later. Per extensive neuropsychological testing in 2010-15, 28% (41/148) of participants met the study definition of clinically relevant cognitive impairment (two or more of 7 select test scores ≥1.5SD worse than demographically appropriate published norms). Logistic regression models with backward selection were constructed for statistical analysis.

resultsMean age and T1D duration at first CAC measure were 37 and 29 years, respectively. A greater burden of initial CAC was associated with cognitive impairment determined 14 years later. Compared to Agatston score = 0, odds ratio (OR) and 95% confidence intervals (CI) of 0<-100, 100<-300 and >300 were 1.4 (0.6, 3.6), 2.3 (0.6, 9.7), and 7.9 (1.6, 38.5), respectively. With both initial and progression of CAC in the multivariable model, backward selection retained only CAC progression, showing it was significantly associated with cognitive impairment (OR [95% CI]: 1.7 [1.1, 2.9]). In those with an initial CAC>0, CAC density was marginally, inversely, associated with cognitive impairment when controlling for CAC volume (OR [95%CI]: 0.3 (0.1, 1.2), p value = 0.078).

conclusionsGreater CAC burden was associated with clinically relevant cognitive impairment in middle-aged adults with childhood-onset T1D. CAC progression appears to be a more powerful predictor than initial calcification.

Indexed as

AdolescentAdultAnkle Brachial IndexCalcinosisChildCognitive DysfunctionCoronary Artery DiseaseDiabetes ComplicationsDiabetes Mellitus, Type 1Disease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsCognitive impairmentCoronary artery calcificationType 1 diabetes

Identifiers

PMID30471556
PMCPMC6584032
OpenAlexW2899746971

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.