ArticleThe Journal of cell biology1988
Studies on cardiac myofibrillogenesis with antibodies to titin, actin, tropomyosin, and myosin.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 155 citations in OpenAlex.
- Inhibitors of the ubiquitin proteasome system block myofibril assembly in cardiomyocytes derived from chick embryos and human pluripotent stem cells.Cytoskeleton (Hoboken, N.J.) · 2021Article
- Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes.Scientific reports · 2017Article
- Exon- and contraction-dependent functions of titin in sarcomere assembly.Development (Cambridge, England) · 2016Article
- Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Preparation of developing Xenopus muscle for sarcomeric protein localization by high-resolution imaging.Methods (San Diego, Calif.) · 2014Article
- DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila.PLoS genetics · 2014Article
- Article
- Serial measurements of NT-proBNP are predictive of not-high-dose anthracycline cardiotoxicity in breast cancer patients.British journal of cancer · 2011Article
- Scaffolds and chaperones in myofibril assembly: putting the striations in striated muscle.Biophysical reviews · 2011Article
- Assembly and dynamics of myofibrils.Journal of biomedicine & biotechnology · 2010Review
- Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2.Developmental biology · 2009Article
- Myofibril assembly visualized by imaging N-RAP, alpha-actinin, and actin in living cardiomyocytes.Experimental cell research · 2009Article
- Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies.Journal of cellular and molecular medicine · 2009Article
- Expression and alternative splicing of N-RAP during mouse skeletal muscle development.Cell motility and the cytoskeleton · 2008Article
- Role of nonmuscle myosin IIB and N-RAP in cell spreading and myofibril assembly in primary mouse cardiomyocytes.Cell motility and the cytoskeleton · 2008Article
- Cardiomyocyte cytoskeleton and myofibrillogenesis in healthy and diseased heart.Heart failure reviews · 2000Review
- I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure.The Journal of cell biology · 1999Article
- Thin filament protein dynamics in fully differentiated adult cardiac myocytes: toward a model of sarcomere maintenance.The Journal of cell biology · 1999Article
- Stepwise dynamics of connecting filaments measured in single myofibrillar sarcomeres.Biophysical journal · 1998Article
- Cell-specific transcription of the smooth muscle gamma-actin gene requires both positive- and negative-acting cis elements.Gene expression · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac myofibrillogenesis was examined in cultured chick cardiac cells by immunofluorescence using antibodies against titin, actin, tropomyosin, and myosin. Primitive cardiomyocytes initially contained stress fiber-like structures (SFLS) that stained positively for alpha actin and/or muscle tropomyosin. In some cases the staining for muscle tropomyosin and alpha actin was disproportionate; this suggests that the synthesis and/or assembly of these two isoforms into the SFLS may not be stoichiometric. The alpha actin containing SFLS in these myocytes could be classified as either central or peripheral; central SFLS showed developing sarcomeric titin while peripheral SFLS had weak titin fluorescence and a more uniform stain distribution. Sarcomeric patterns of titin and myosin were present at multiple sites on these structures. A pair of titin staining bands was clearly associated with each developing A band even at the two or three sarcomere stage, although occasional examples of a titin band being associated with a half sarcomere were noted. The appearance of sarcomeric titin patterns coincided or preceded sarcomere periodicity of either alpha actin or muscle tropomyosin. The early appearance of titin in myofibrillogenesis suggests it may have a role in filament alignment during sarcomere assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.