Evidence map›Paper›PMID 30471347›Full record

ArticleFree radical biology & medicine2019

Synthesis and evaluation of

Keita Saito, Deepak Sail, Kazutoshi Yamamoto, Shingo Matsumoto, Burchelle Blackman, Shun Kishimoto, Jeffrey R Brender, Rolf E Swenson, James B Mitchell, Murali C Krishna

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. HyperpolarizedAntioxidants & redox signaling · 2022
    Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keita SaitoRadiation Biology Branch, National Cancer Institute, Bethesda, MD, USA.
Deepak SailImaging Probe Development Center, National Heart, Lung, and Blood Institute, Rockville, MD, USA.
Kazutoshi YamamotoRadiation Biology Branch, National Cancer Institute, Bethesda, MD, USA.
Shingo MatsumotoGraduate School of Information Science and Technology, Hokkaido University, Sapporo, Hokkaido, Japan.
Burchelle BlackmanImaging Probe Development Center, National Heart, Lung, and Blood Institute, Rockville, MD, USA.
Shun KishimotoRadiation Biology Branch, National Cancer Institute, Bethesda, MD, USA.
Jeffrey R BrenderRadiation Biology Branch, National Cancer Institute, Bethesda, MD, USA.
Rolf E SwensonImaging Probe Development Center, National Heart, Lung, and Blood Institute, Rockville, MD, USA.
James B MitchellRadiation Biology Branch, National Cancer Institute, Bethesda, MD, USA.
Murali C KrishnaRadiation Biology Branch, National Cancer Institute, Bethesda, MD, USA. Electronic address: murali@helix.nih.gov.

Funding

Imaging Probe Development CenterZICHL005090 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SWENSON, ROLF · 2011 to 2025
$22.2M
Overhauser Enhanced Magnetic Resonance Imaging (OMRI)ZIABC010477 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHERUKURI, MURALI · 2009 to 2025
$16.1M
Overhauser Enhanced Magnetic Resonance Imaging (OMRI)Z01BC010477 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHERUKURI, MURALI · 2003 to 2008
$732k
Intramural NIH HHS Z01 BC010477
6 · The paper itself

Abstract

Effective means to identify the role of reactive oxygen species (ROS) mediating several diseases including cancer, ischemic heart disease, stroke, Alzheimer's and other inflammatory conditions in in vivo models would be useful. The cyclic nitrone 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) is a spin trap frequently used to detect free radicals in vitro using Electron Paramagnetic Resonance (EPR) spectroscopy. In this study, we synthesized

Indexed as

AnimalsCarbon IsotopesCyclic N-OxidesDeuteriumFemaleHeartKidneyLungMagnetic Resonance ImagingMiceMice, Inbred C3HReactive Oxygen SpeciesSpin LabelsSpin Trapping5,5-dimethyl-1-pyrroline-1-oxideCarbon IsotopesCyclic N-OxidesDeuteriumReactive Oxygen SpeciesSpin LabelsDMPO: reactive oxygen speciesHyperpolarized (13)C-MRISpin trapping

Identifiers

PMID30471347
PMCPMC6983923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.