ArticleDevelopmental science2019
Evidence for a sensitive period in the effects of early life stress on hippocampal volume.
Article in Developmental science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Brain structure and function in adult survivors of developmental trauma with psychosis: A systematic review.Psychological medicine · 2025Pooled it
- Adverse Childhood Events and Health Biomarkers: A Systematic Review.Frontiers in public health · 2021Pooled it
- Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- The Impact of Childhood Trauma on Neuropsychological Disorders and Its Intergenerational Transmission Mechanisms.Behavioral sciences (Basel, Switzerland) · 2026Review
- Social withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability.Schizophrenia research · 2026Article
- Adverse Childhood Experiences and Growth Outcomes in Childhood: A Longitudinal EHR-Based Study.medRxiv : the preprint server for health sciences · 2026Article
- Development and validation of the lifetime sense of safety scale in Kenyan adults.Communications medicine · 2026Article
- Maternal mood entropy and children's hippocampal development: Enduring versus transient effects.Development and psychopathology · 2026Article
- The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Decreased hippocampal neurite density in late-middle-aged adults following prenatal exposure to higher levels of maternal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Life Course Financial Hardship and Fecundability in a North American Preconception Cohort Study.Epidemiology (Cambridge, Mass.) · 2025Article
- Multivariate Links Between the Developmental Timing of Adversity Exposure and White Matter Tract Connectivity in Adulthood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Decreased hippocampal neurite density in late middle-aged adults following prenatal exposure to higher levels of maternal inflammation.bioRxiv : the preprint server for biology · 2025Article
- Associations Between Experience of Typical Variations in Stressors and Hippocampal Structure and Functional Connectivity in Childhood.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Patterns of early childhood adversity and neighborhood deprivation predict unique challenges in adolescence: A UK birth cohort study.Development and psychopathology · 2025Article
- A sensitive period for the development of episodic-like memory in mice.Current biology : CB · 2025Article
- Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress.Frontiers in cellular neuroscience · 2025Article
- The impact of parenting styles on depression among high-risk adolescents of different genders in chinese urban samples: the mediating effects of adverse childhood experiences and learning burnout.Frontiers in psychiatry · 2025Article
- A teacher's perceptions of the impacts of the Zero Violence Brave Club in students' wellbeing.AIMS neuroscience · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Exposure to stress has been causally linked to changes in hippocampal volume (HV). Given that the hippocampus undergoes rapid changes in the first years of life, stressful experiences during this period may be particularly important in understanding individual differences in the development of the hippocampus. One hundred seventy-eight early adolescents (ages 9-13 years; 43% male) were interviewed regarding exposure to and age of onset of experiences of stress; the severity of each stressful event was rated by an objective panel. All participants underwent structural magnetic resonance imaging, from which HVs were automatically segmented. Without considering the age of onset for stressful experiences, there was a small but statistically significant negative association of stress severity with bilateral HV. When considering the age of onset, there was a moderate and significant negative association between stress severity during early childhood (through 5 years of age) and HV; there was no association between stress severity during later childhood (age 6 years and older) and HV. We provide evidence of a sensitive period through 5 years of age for the effects of life stress on HV in adolescence. It will be important in future research to elucidate how reduced HV stemming from early life stress may contribute to stress-related health outcomes.
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