Evidence map›Paper›PMID 30471114›Full record

ReviewThe Journal of physiology2019

Challenges and advances in atomistic simulations of potassium and sodium ion channel gating and permeation.

Kevin R DeMarco, Slava Bekker, Igor Vorobyov

Abstract readReview
In one paragraph

Review in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Ion channel selectivity through ion-modulated changes of selectivity filter pProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Article
  4. Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel.Journal of chemical information and modeling · 2023
    Article
  5. Mutation-Specific Differences in Kv7.1 (International journal of molecular sciences · 2022
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Conductance selectivity of NaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Selectivity filter modalities and rapid inactivation of the hERG1 channel.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin R DeMarcoDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA, USA.ORCID 0000-0001-6581-2497
Slava BekkerDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA, USA.ORCID 0000-0002-8014-7023
Igor VorobyovDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA, USA.ORCID 0000-0002-4767-5297

Funding

Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
In silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7M
Predictive multiscale in silico cardio-pharmacologyU01HL126273 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E · 2015 to 2019
$3.8M
NHLBI NIH HHS R01 HL128537NHLBI NIH HHS U01 HL126273NIH HHS OT2 OD026580
6 · The paper itself

Abstract

Ion channels are implicated in many essential physiological events such as electrical signal propagation and cellular communication. The advent of K

Indexed as

Binding SitesHumansIon Channel GatingIon ChannelsMolecular Dynamics SimulationPotassiumSodiumIon ChannelsPotassiumSodiuminactivationKcsAknock-on mechanismmembrane proteinmolecular dynamicssliding helixvoltage gated ion channelvoltage sensor

Identifiers

PMID30471114
PMCPMC6355641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.