ArticleJournal of the American Geriatrics Society2019
Effect of Age on Opioid Prescribing, Overdose, and Mortality in Massachusetts, 2011 to 2015.
Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Development and validation of a risk-score model for opioid overdose using a national claims database.Scientific reports · 2022Trial
- Association between early mobilization after hip fracture surgery and risk of long-term opioid therapy.European geriatric medicine · 2025Article
- A Longitudinal Multivariable Analysis: State Policies and Opioid Dispensing in Medicare Beneficiaries Undergoing Surgery.Journal of general internal medicine · 2024Article
- Risk of Mortality Associated with Potentially Inappropriate Medication Use Including Opioids in Older Adults.Drug safety · 2024Article
- Growing importance of high-volume buprenorphine prescribers in OUD treatment: 2009-2018.Drug and alcohol dependence · 2024Observational
- Health care system costs related to potentially inappropriate medication use involving opioids in older adults in Canada.BMC health services research · 2023Article
- Use of Big Data and Ethical Issues for Populations With Substance Use Disorder.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2023Article
- National Trends in Buprenorphine Treatment for Opioid Use Disorder From 2007 to 2018.Substance abuse · 2023Observational
- An Exploratory Analysis of Differential Prescribing of High-Risk Opioids by Insurance Type Among Patients Seen by the Same Clinician.Journal of general internal medicine · 2023Article
- Sociodemographic differences in quality of treatment to Medicaid enrollees receiving buprenorphine.Substance abuse · 2022Article
- Risk of an Opioid-Related Emergency Department Visit or Hospitalization Among Older Breast, Colorectal, Lung, and Prostate Cancer Survivors.Mayo Clinic proceedings · 2022Article
- The effect of state policies on rates of high-risk prescribing of an initial opioid analgesic.Drug and alcohol dependence · 2022Article
- Individual and Community Factors Associated with Naloxone Co-prescribing Among Long-term Opioid Patients: a Retrospective Analysis.Journal of general internal medicine · 2021Article
- Linkage of public health and all payer claims data for population-level opioid research.Pharmacoepidemiology and drug safety · 2021Article
- Poly-prescription drug misuse across the life course: Prevalence and correlates across different adult age cohorts in the U.S.The International journal on drug policy · 2021Article
- Article
- Opioid initiation and injection transition in rural northern New England: A mixed-methods approach.Drug and alcohol dependence · 2020Article
- A qualitative study of big data and the opioid epidemic: recommendations for data governance.BMC medical ethics · 2020Article
- Heterogeneity in Prescription Opioid Pain Reliever Misuse Across Age Groups: 2015-2017 National Survey on Drug Use and Health.Journal of general internal medicine · 2020Article
- Who receives naloxone from emergency medical services? Characteristics of calls and recent trends.Substance abuse · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesTo examine the effect of age on the likelihood of PIP of opioids and the effect of PIP on adverse outcomes.
designRetrospective cohort study.
settingData from multiple state agencies in Massachusetts from 2011 to 2015.
participantsAdult Massachusetts residents (N=3,078,163) who received at least one prescription opioid during the study period; approximately half (1,589,365) aged 50 and older. MEASUREMENTS: We measured exposure to 5 types of PIP: high-dose opioids, coprescription with benzodiazepines, multiple opioid prescribers, multiple opioid pharmacies, and continuous opioid therapy without a pain diagnosis. We examined 3 adverse outcomes: nonfatal opioid overdose, fatal opioid overdose, and all-cause mortality.
resultsThe rate of any PIP increased with age, from 2% of individuals age 18 to 29 to 14% of those aged 50 and older. Older adults also had higher rates of exposure to 2 or more different types of PIP (40-49, 2.5%; 50-69, 5%; ≥70, 4%). Of covariates assessed, older age was the greatest predictor of PIP. In analyses stratified according to age, any PIP and specific types of PIP were associated with nonfatal overdose, fatal overdose, and all-cause mortality in younger and older adults.
conclusionOlder adults are more likely to be exposed to PIP, which increases their risk of adverse events. Strategies to reduce exposure to PIP and to improve outcomes in those already exposed will be instrumental to addressing the opioid crisis in older adults. J Am Geriatr Soc 67:128-132, 2019.
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