ArticleGeneral thoracic and cardiovascular surgery2019
Long agonal period deteriorates cardiac death donor lung function in a rat EVLP model.
Article in General thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A translational rat model for ex vivo lung perfusion of pre-injured lungs after brain death.PloS one · 2021Article
- Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse.General thoracic and cardiovascular surgery · 2020Article
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Authors and funding
8 authors.
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Abstract
purposeWe investigated the impact of the duration of agonal period on donor lung function after reperfusion in an ex vivo rat lung perfusion model.
methodsThree mechanical hypoventilation conditions were used for three agonal periods, which were defined as the interval between the start of hypoventilation and the time when systolic arterial blood pressure reached < 50 mmHg, i.e., < 10, 30-60, and 150-200 min for very short (VS), short (S), and long (L) groups (n = 5 rats/group). After flushing the lung, heart-lung blocks were reperfused ex vivo for 120 min; physiological data were obtained throughout the reperfusion process.
resultsPulmonary vascular resistance was significantly higher throughout reperfusion in group L than in the other two groups (p < 0.05). After reperfusion, oxygenation was worse and pulmonary edema was more severe in group L than in group S (p < 0.05). Potassium concentrations in the perfusates were significantly higher in group L than in group VS. Histological analysis revealed more severe injury in group L than in the other two groups.
conclusionsLong agonal periods may lead to deterioration of donor lung function; short intervals may not significantly affect donor lung function.
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