ArticleDigestive diseases and sciences2019
NAFLD Induction Delays Postoperative Liver Regeneration of ALPPS in Rats.
Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Optical Coherence Tomography Angiography, Elastography, and Attenuation Imaging for Evaluation of Liver Regeneration.Diagnostics (Basel, Switzerland) · 2025Article
- Perioperative treatment with cilostazol reverses steatosis and improves liver regeneration after major hepatectomy in a steatotic rat model.Scientific reports · 2025Article
- Correlation between the liver transection line localization and future liver remnant hypertrophy in associating liver partition and portal vein ligation for staged hepatectomy.Frontiers in surgery · 2024Article
- Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice.Biology open · 2023Article
- Corosolic acid inhibits tumour growth without compromising associating liver partition and portal vein ligation-induced liver regeneration in rats.Annals of medicine · 2022Article
- Folinic Acid Potentiates the Liver Regeneration Process after Selective Portal Vein Ligation in Rats.Cancers · 2022Article
- Verapamil induces autophagy to improve liver regeneration in non-alcoholic fatty liver mice.Adipocyte · 2021Article
- Mechanisms of nonalcoholic fatty liver disease and implications for surgery.Langenbeck's archives of surgery · 2021Review
- Modulation of Autophagy: A Novel "Rejuvenation" Strategy for the Aging Liver.Oxidative medicine and cellular longevity · 2021Review
- Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division.Hepatology international · 2020Review
- The Role of Autophagy for the Regeneration of the Aging Liver.International journal of molecular sciences · 2020Review
- Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging?Analytical cellular pathology (Amsterdam) · 2019Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssociating liver partition and portal vein ligation (ALPPS) is a promising two-step hepatectomy that is beneficial for accumulative regeneration of the future liver remnant (FLR) and avoids postoperative liver failure.
aimsOur study aimed to evaluate whether nonalcoholic fatty liver disease affected the liver regeneration induced by ALPPS.
methodsSprague-Dawley rats fed a high-fat diet were used to construct the NAFLD model. ALPPS were performed, and blood and future liver remnant samples were collected at postoperative days 1 (POD1), POD3, and POD7.
resultsThe hepatic regeneration rate (HRR) of ALPPS was higher than that of portal vein ligation (PVL) at POD3 and POD7 (p < 0.05), and the number of Ki-67-positive hepatocytes (POD3) and CD68-positive Kupffer cells (POD7) per visual field was higher in the ALPPS group than in the PVL group (p < 0.05). The serum TNF-α, hepatocyte growth factor protein, and the serum IL-6 level were higher in the ALPPS group than in the PVL group at POD3 and POD7. Compared with those of the standard laboratory diet (SLD)-fed rats, the rats with NAFLD exhibited a decrease in the HRR, Ki-67-positive hepatocytes, and CD68-positive Kupffer cells in the FLR. The number of CD68-positive Kupffer cells was lower in rats with NAFLD than that in SLD-fed rats; noteworthily, the serum level of IL-6 and TNF-α changed dramatically after surgeries.
conclusionsNAFLD induction delayed liver regeneration induced by the ALPPS procedure, which might be associated with hepatocyte proliferation and the number of Kupffer cells.
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