ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2019
Functional neuroimaging of the central autonomic network: recent developments and clinical implications.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 3 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Is cardiac autonomic control affected in major depressive disorder? A systematic review of heart rate variability studies.Translational psychiatry · 2025Pooled it
- Unveiling the role of cerebellar alterations in the autonomic nervous system: a systematic review of autonomic dysfunction in spinocerebellar ataxias.Journal of neurology · 2023Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Tai Chi's synergistic modulation on autonomic nervous activity and central autonomic networks in functional constipation patients: a randomized controlled trial.Scientific reports · 2025Trial
- Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories.Behavioural brain research · 2024Trial
- Heart Rate Variability Features as Predictors of Intermittent Theta-Burst Stimulation Response in Posttraumatic Stress Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2022Trial
- The Human Intracerebral EEG Platform: A Cloud-Based Trusted Research Environment for Collaborative SEEG Research in Epilepsy and Neuroscience.European journal of neurology · 2026Review
- Goosebumps and chills: bilateral piloerection as a manifestation of right mesial temporal epilepsy.Epilepsy & behavior reports · 2026Article
- Brain-heart interactions in late-onset major depressive disorder revealed by multimodal HRV-driven fMRI.Communications biology · 2026Article
- Disentangling Respiratory Phase-Dependent and Phase-Independent Components of Anticipatory Cardiac Deceleration.Psychophysiology · 2026Article
- Shared Neurocardiac Pathways Linking Atrial Fibrillation and Depression: A UK Biobank Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Disease duration modulates BOLD representations of alpha oscillations in drug-resistant epilepsy: A concurrent EEG and fMRI study.Epilepsia · 2026Article
- MRI methods for the study of central nervous system involvement in autonomic function.Frontiers in network physiology · 2026Review
- Multimodal MRI to elucidate cross-organ coupling mechanisms of the heart-brain axis.Frontiers in cardiovascular medicine · 2026Review
- Resting-State Heart Rate Variability and Symptom-Level Conditional Associations in Hospitalized Patients with Musculoskeletal Pain: An Exploratory Cross-Sectional Network Analysis.Journal of pain research · 2026Article
- Cardiovascular Activity Predominantly Modulates Brain Dynamics in Non-REM Sleep Transitions.Annals of the New York Academy of Sciences · 2026Article
- Coupling of Rhythms in Prefrontal Cortex and Autonomic Nervous System in School-Age Children.Annals of the New York Academy of Sciences · 2026Article
- Bidirectional brain-heart communication in coronary heart disease: from coronary plaques to central autonomic networks.Frontiers in neuroscience · 2026Review
- Resting-state functional connectivity related to empathy and sensory processing sensitivity.Frontiers in human neuroscience · 2026Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe central autonomic network (CAN) is an intricate system of brainstem, subcortical, and cortical structures that play key roles in the function of the autonomic nervous system. Prior to the advent of functional neuroimaging, in vivo studies of the human CAN were limited. The purpose of this review is to highlight the contribution of functional neuroimaging, specifically functional magnetic resonance imaging (fMRI), to the study of the CAN, and to discuss recent advances in this area. Additionally, we aim to emphasize exciting areas for future research.
methodsWe reviewed the existing literature in functional neuroimaging of the CAN. Here, we focus on fMRI research conducted in healthy human subjects, as well as research that has been done in disease states, to understand CAN function. To minimize confounding, papers examining CAN function in the context of cognition, emotion, pain, and affective disorders were excluded.
resultsfMRI has led to significant advances in the understanding of human CAN function. The CAN is composed of widespread brainstem and forebrain structures that are intricately connected and play key roles in reflexive and modulatory control of autonomic function.
conclusionsfMRI technology has contributed extensively to current knowledge of CAN function. It holds promise to serve as a biomarker in disease states. With ongoing advancements in fMRI technology, there is great opportunity and need for future research involving the CAN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.