ReviewPlanta2019
A hypothesis about the origin of carotenoid lipid droplets in the green algae Dunaliella and Haematococcus.
Review in Planta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 101 citations in OpenAlex.
- Synergistic Application of Cytidine Monophosphate and Sodium Chloride for Enhanced Co-Production of Astaxanthin and Fatty Acids inMarine drugs · 2026Article
- Chloroplast budding mediates β-carotene transport for early stage astaxanthin hyperaccumulation in microalgae.Plant physiology · 2025Article
- Functional study of Phaeodactylum tricornutum Seipin highlights specificities of lipid droplets biogenesis in diatoms.The New phytologist · 2025Article
- Multimodal non-invasive probing of stress-induced carotenogenesis in the cells of microalga Bracteacoccus aggregatus.Protoplasma · 2024Article
- Illuminating the diversity of carotenoids in microalgal eyespots and phototaxis.Plant signaling & behavior · 2023Review
- The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics.Marine drugs · 2023Review
- Zeaxanthin is required for eyespot formation and phototaxis in Euglena gracilis.Plant physiology · 2023Article
- Characterization of the Wave Phenomenon in Flash-Induced Fluorescence Relaxation and Its Application to Study Cyclic Electron Pathways in Microalgae.International journal of molecular sciences · 2022Article
- Comparative morphological, physiological, biochemical and genomic studies reveal novel genes of Dunaliella bioculata and D. quartolecta in response to salt stress.Molecular biology reports · 2022Article
- Transcriptomic and Proteomic Characterizations of the Molecular Response to Blue Light and Salicylic Acid inMarine drugs · 2021Article
- Enhancement of astaxanthin accumulation using black light in Coelastrum and Monoraphidium isolated from Malaysia.Scientific reports · 2021Article
- Challenges and Potential in Increasing Lutein Content in Microalgae.Microorganisms · 2021Review
- Characterization of type-2 diacylglycerol acyltransferases in Haematococcus lacustris reveals their functions and engineering potential in triacylglycerol biosynthesis.BMC plant biology · 2021Article
- Metabolic Engineering of Non-carotenoid-Producing YeastFrontiers in microbiology · 2021Article
- Article
- Transcription Factors FromFrontiers in bioengineering and biotechnology · 2021Article
- Spatiotemporal monitoring of intracellular metabolic dynamics by resonance Raman microscopy with isotope labeling.RSC advances · 2020Article
- A Review of Diatom Lipid Droplets.Biology · 2020Review
- Phytoene Accumulation in the Novel MicroalgaMarine drugs · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAIN
conclusionHypercarotenogenesis in green algae evolved by mutation of PSY that increased its transcription at high light, disintegration of the eyespot in Dunaliella and acquisition of the capacity to export carotenoids from chloroplasts in Haematococcus. Carotenoids (Car) are lipid-soluble pigments synthesized in plants, algae, bacteria and fungi. Car have strong antioxidative properties and as such are utilized to reduce the danger of different diseases in humans. Two green microalgae are utilized as rich natural sources for Car: Dunaliella salina/bardawil accumulates 10% (w/w) β-carotene (βC), which is also pro-vitamin A, and Haematococcus pluvialis accumulates 4% (w/w) astaxanthin (Ast), the strongest antioxidant among Car. D. bardawil accumulates βC in plastoglobules within the chloroplast, whereas H. pluvialis deposits Ast in cytoplasmic lipid droplets (CLD). In this review we compare the hypercarotenogenic responses (HCR) in Dunaliella and in Haematococcus and try to outline hypothetical evolutionary pathways for its origin. We propose that a mutation in phytoene synthetase that increased its transcription level in response to high light stress had a pivotal role in the evolution of the HCR. Proteomic analyses indicated that in D. bardawil/salina the HCR evolved from dissociation and amplification of eyespot lipid globules. The more robust HCR in algae that accumulate carotenoids in CLD, such as H. pluvialis, required also acquisition of the capacity to export βC out of the chloroplast and its enzymatic conversion into Ast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.