SynthesisInternational orthopaedics2019
Adjacent segment degeneration after fusion spinal surgery-a systematic review.
Synthesis in International orthopaedics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06989632 (Total Lumbar Disc Prosthesis and Subsequent Work Activity 5 Years After Total Lumbar Disc Replacement), which is not on this map. Cited by 132 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total Lumbar Disc Prosthesis and Subsequent Work Activity 5 Years After Total Lumbar Disc Replacement
Who cites it
132 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Impact of iatrogenic alterations on adjacent segment degeneration after lumbar fusion surgery: a systematic review.Journal of orthopaedic surgery and research · 2025Pooled it
- Medium and long-term radiographic and clinical outcomes of Dynesys dynamic stabilization versus instrumented fusion for degenerative lumbar spine diseases.BMC surgery · 2023Pooled it
- Superior facet joint violation between open and minimally invasive techniques in lumbar fusion surgery: An updated systematic review and meta-analysis.Journal of the Chinese Medical Association : JCMA · 2023Pooled it
- Complications of cervical total disc replacement and their associations with heterotopic ossification: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Pooled it
- Moment-rotation behavior of intervertebral joints in flexion-extension, lateral bending, and axial rotation at all levels of the human spine: A structured review and meta-regression analysis.Journal of biomechanics · 2020Pooled it
- Development and validation of explainable machine learning models to predict the risk of adjacent segment disease after lumbar fusion surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Effect of Axial and Coronal Malalignment on Polyethylene Stresses in Lumbosacral Total Joint Replacement: A Finite Element Study.Bioengineering (Basel, Switzerland) · 2026Article
- Adjacent segment disease following long segment instrumentation of lumbar spine: A finite element analysis study.The Indian journal of medical research · 2026Article
- Sarcopenia, paraspinal muscle degeneration, and bone quality as prognostic factors for adjacent segment degeneration or disease after lumbar fusion: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Upright MRI Follow-Up for Decompression and Interlaminar Stabilization in Low-Grade L4/L5 Spondylolisthesis Suggests Reduced Reoperation Rates Compared With Fusion or Decompression Alone.International journal of spine surgery · 2026Article
- Pre-scan prediction of postoperative MRI reliability for the spinal canal and neural foramina using localizer images in patients with lumbar instrumentation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Endoscopic and percutaneous minimally invasive repair of pars interarticularis defects: a systematic review of clinical outcomes.Spine deformity · 2026Review
- Comparison of Stand-Alone Cage versus Intervertebral Cage with Pedicle Screw and Rod Fixation in Dogs with Degenerative Lumbosacral Stenosis.Veterinary and comparative orthopaedics and traumatology : V.C.O.T · 2026Article
- Review
- Stem Cells and their Key Derivatives in Degenerative Musculoskeletal Diseases.Stem cell reviews and reports · 2026Review
- Synergetic mechanism by decompression and bone bioactive factors to induce the spontaneous resolution of lumbar disc herniation.Scientific reports · 2026Article
- Preoperative geriatric nutritional risk index is a reliable tool for predicting postoperative adjacent segment disease among elderly patients with degenerative lumbar diseases: a case control study.BMC musculoskeletal disorders · 2026Article
- Novel 360° lumbar arthroplasty: Surgical technique and procedural details.North American Spine Society journal · 2026Article
- Dynamic posterior stabilization for traumatic lumbar facet fracture: A case report.North American Spine Society journal · 2026Article
- Minimally Invasive Lateral Lumbar Interbody Fusion Shows a Lower Incidence of Radiologic Adjacent Segment Pathology Than Conventional Posterior Lumbar Interbody Fusion.Journal of Korean medical science · 2026Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdjacent segment degeneration (ASDeg) and disease (ASDis) have become major concerns after fusion surgery. However, there is no definitive data or knowledge about the incidence or risk factors. The review discusses the incidence and risk factors and prevention of ASDeg and ASDis in the relevant literature.
methodsWe performed a systematic review of meta-analyses, randomized control trials, and cohort studies published in English to provide evidence-based information about ASDeg and ASDis.
resultsAccording to a meta-analysis, the pooled incidence of ASDeg after lumbar and cervical fusion surgery was 26.6% and 32.8%, respectively. Approximately 1/4-1/3 of ASDeg progressed to ASDis. Risk factors after cervical fusion surgery were young age, pre-existing disc degeneration, short fusion segment, high T1 slope, disruption of adjacent soft tissue, and plate placement close to the adjacent disc. The risk factors of ASDeg and ASDis after lumbar fusion surgery were age, genetic factors, high body mass index, pre-existing adjacent segment degeneration, laminectomy at the adjacent level of fusion, excessive distraction of the fusion level, insufficient lumbar lordosis, multilevel fixation, floating fusion, coronal wedging of L5-S disc, pelvic tilt, and osteoporosis. Motion-preserving surgeries seem to have less risk of ASDeg and ASDis than conventional fusion surgery both in the lumbar and cervical spine.
conclusionsThe existent literature points out variables involved in ASDeg and ASDis. High evidence-level studies should provide more relevant data to guide strategies for avoiding ASDeg and ASDis.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.