Evidence map›Paper›PMID 30470847›Full record

ArticleClinical neuroradiology2020

Automated CT Perfusion Imaging Versus Non-contrast CT for Ischemic Core Assessment in Large Vessel Occlusion.

Anderson Chun On Tsang, Stephanie Lenck, Christopher Hilditch, Patrick Nicholson, Waleed Brinjikji, Timo Krings, Vitor M Pereira, Frank L Silver, Joanna D Schaafsma

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Diagnosis of Ischemic Stroke: As Simple as Possible.Diagnostics (Basel, Switzerland) · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 3 countries.

Anderson Chun On TsangDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Canada. acotsang@hku.hk.ORCID http://orcid.org/0000-0003-2758-3253
Stephanie LenckDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Canada.
Christopher HilditchDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Canada.
Patrick NicholsonDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Canada.
Waleed BrinjikjiDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Canada.
Timo KringsDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Canada.
Vitor M PereiraDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Canada.
Frank L SilverDepartment of Neurology, Toronto Western Hospital, Toronto, Canada.
Joanna D SchaafsmaDepartment of Neurology, Toronto Western Hospital, Toronto, Canada.
Toronto Western Hospital · CA

Funding

Health and Medical Research Fund 01150027
6 · The paper itself

Abstract

purposeThere is increasing use of automated computed tomography perfusion (CTP) to aid thrombectomy decision in emergent large vessel occlusion. It is important to understand the performance of these software packages in predicting ischemic core and tissue-at-risk in the real-world setting. The aim of this study was to evaluate whether ischemic core on non-contrast CT (NCCT) and automated CTP correspond and predict infarct extent after thrombectomy for ischemic stroke.

methodsConsecutive patients with acute anterior circulation large vessel occlusion undergoing successful thrombectomy (TICI 2b/3) were studied. All patients had baseline CT, CTP with RAPID post-processing software (RAPID-CTP), and post-thrombectomy 24 h CT. Ischemic cores were assessed by two blinded raters independently using the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) on each modality. The interrater agreement for ASPECTS, and correlation between baseline CT-ASPECTS, RAPID-CTP-ASPECTS, and 24h CT-ASPECTS were calculated.

resultsA total of 86 patients with a mean age of 70.3 years (SD 16.5) were studied. The median baseline CT-ASPECTS was 9.5 (interquartile range, IQR 8-10), median RAPID-CTP-ASPECTS was 9 (IQR 8-10), and mean RAPID-CTP-ischemic core volume was 14.4 ml (SD 27.9 ml). The mean mismatch volume (difference of Tmax > 6s and cerebral blood flow (CBF) < 30%) was 128.6 ml (SD 126.0 ml). There was substantial correlation between baseline and 24h CT-ASPECTS (r

conclusionIn this series of successfully revascularized patients, ischemic core as estimated by RAPID-CTP-ASPECTS did not correlate with the baseline CT and tended to depict a larger infarct core than the infarct extent as assessed by 24h CT-ASPECTS.

Indexed as

AgedArterial Occlusive DiseasesBrain IschemiaCerebral AngiographyCerebrovascular CirculationCohort StudiesComputed Tomography AngiographyFemaleHumansMalePerfusion ImagingReproducibility of ResultsRetrospective StudiesStrokeThrombectomyEndovascular thrombectomyIschemic strokeLarge vessel occlusionRAPIDStroke imaging

Identifiers

PMID30470847
OpenAlexW2901459009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.