Evidence map›Paper›PMID 30470839›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019

Predator odor increases avoidance and glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling.

Lara S Hwa, Sofia Neira, Melanie M Pina, Dipanwita Pati, Rachel Calloway, Thomas L Kash

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  12. Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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  18. Prelimbic cortex glucocorticoid receptors regulate the stress-mediated inhibition of pain contagion in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  19. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lara S HwaDepartments of Pharmacology, Neuroscience, and the Bowles Alcohol Research Center, University of North Carolina School of Medicine, 104 Manning Drive, Chapel Hill, NC, 27599, USA.
Sofia NeiraDepartments of Pharmacology, Neuroscience, and the Bowles Alcohol Research Center, University of North Carolina School of Medicine, 104 Manning Drive, Chapel Hill, NC, 27599, USA.
Melanie M PinaDepartments of Pharmacology, Neuroscience, and the Bowles Alcohol Research Center, University of North Carolina School of Medicine, 104 Manning Drive, Chapel Hill, NC, 27599, USA.
Dipanwita PatiDepartments of Pharmacology, Neuroscience, and the Bowles Alcohol Research Center, University of North Carolina School of Medicine, 104 Manning Drive, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-6303-4871
Rachel CallowayDepartments of Pharmacology, Neuroscience, and the Bowles Alcohol Research Center, University of North Carolina School of Medicine, 104 Manning Drive, Chapel Hill, NC, 27599, USA.
Thomas L KashDepartments of Pharmacology, Neuroscience, and the Bowles Alcohol Research Center, University of North Carolina School of Medicine, 104 Manning Drive, Chapel Hill, NC, 27599, USA. tkash@email.unc.edu.ORCID 0000-0002-4747-4495
University of North Carolina at Chapel Hill · US

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Clyde W Hodge · 2003 to 2026
$46.3M
RESEARCH TRAINING IN THE NEUROSCIENCEST32NS007431 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juan Song, Mark J. Zylka · 1997 to 2026
$10.0M
Supplement to Molecular and Cellular Studies on Alcohol's ActionsT32AA007573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FULTON T CREWS, Thomas L. Kash · 1997 to 2026
$9.3M
Probing Ethanol Induced Acceleration of Hindbrain and Amygdalar Pathology in an Alzheimer’s Disease ModelU01AA020911 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash, Zoe Anastasia McElligott · 2012 to 2026
$5.8M
The Role of Serotonin in Alcohol-Withdrawal Induced AnxietyR01AA019454 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2010 to 2026
$5.6M
MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISMP50AA011605 · NIAAA · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BREESE, GEORGE R · 1998 to 2002
$4.9M
Osteogenic Progenitor Cells in Skeletal MuscleR01AG020911 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GOLDHAMER, DAVID J · 2001 to 2005
$1.5M
Core 1: Brain Circuit Validation CoreU24AA025475 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KASH, THOMAS L. · 2017 to 2021
$1.1M
Adaptations in an insular cortex microcircuit following escalated alcohol drinkingF32AA026485 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PINA, MELANIE M · 2017 to 2020
$142k
AGING AND MEMORY FOR RELATIONAL AND IMAGERIC INFORMATIONR29AG011605 · NIA · CALIFORNIA STATE UNIVERSITY FRESNO · PI SHARPS, MATTHEW J · 1994 to 1999
–
NIAAA NIH HHS F32 AA026485NIAAA NIH HHS P50 AA011605NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R01 AA019454NIAAA NIH HHS T32 AA007573NIAAA NIH HHS U01 AA020911NIAAA NIH HHS U24 AA025475NINDS NIH HHS T32 NS007431
6 · The paper itself

Abstract

Acute exposure to a salient stressor, such as in post-traumatic stress disorder, can have lasting impacts upon an individual and society. To study stress in rodents, some naturalistic methods have included acute exposure to a predator odor, such as the synthetic fox odor 2,4,5, trimethyl-3-thiazoline (TMT). These experiments explore the stress-related behaviors and cortical activity induced by TMT exposure in adult male C57BL/6J mice and the influence of the stress neuropeptide corticotropin-releasing factor (CRF) on these responses. Compared to H

Indexed as

Aniline CompoundsAnimalsAvoidance LearningBehavior, AnimalCorticotropin-Releasing HormoneCRF Receptor, Type 1Dose-Response Relationship, DrugExcitatory Postsynaptic PotentialsPrefrontal CortexPyrimidinesPyrrolesReceptors, Corticotropin-Releasing HormoneSynaptic TransmissionThiazoles2,4,5 trimethylthiazoline2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidineAniline CompoundsCorticotropin-Releasing HormoneCP 154526CRF Receptor, Type 1PyrimidinesPyrrolesReceptors, Corticotropin-Releasing HormoneThiazoles

Identifiers

PMID30470839
PMCPMC6372588
OpenAlexW2952555065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.