Evidence map›Paper›PMID 30470812›Full record

ArticleScientific reports2018

New insights into mitral heart valve prolapse after chordae rupture through fluid-structure interaction computational modeling.

Andrés Caballero, Wenbin Mao, Raymond McKay, Charles Primiano, Sabet Hashim, Wei Sun

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Coupling Models of Resistive Valves to Muscle Mechanics in Cardiac Fluid-Structure Interaction Simulations.International journal for numerical methods in biomedical engineering · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Analysis of a coupled fluid-structure interaction model of the left atrium and mitral valve.International journal for numerical methods in biomedical engineering · 2019
    Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrés CaballeroThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Wenbin MaoThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-8582-0205
Raymond McKayCardiology and Cardiac Surgery, The Hartford Hospital, Hartford, Connecticut, USA.
Charles PrimianoCardiology and Cardiac Surgery, The Hartford Hospital, Hartford, Connecticut, USA.
Sabet HashimCardiology and Cardiac Surgery, The Hartford Hospital, Hartford, Connecticut, USA.
Wei SunThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. wei.sun@bme.gatech.edu.
Georgia Institute of Technology · USHartford Hospital · US

Funding

Probabilistic Modeling of Stenotic Aortic Valve InterventionR01HL104080 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI SUN, WEI · 2011 to 2015
$1.9M
Biomechanical study on aortic-mitral coupling in transcatheter aortic valve replacementR21HL127570 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI SUN, WEI · 2016 to 2017
$441k
American Heart Association (American Heart Association, Inc.) 15POST25910002NHLBI NIH HHS R01 HL104080NHLBI NIH HHS R21 HL127570U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL104080U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL127570
6 · The paper itself

Abstract

Mitral valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.

Indexed as

Computer SimulationModels, CardiovascularAgedAged, 80 and overChordae TendineaeFemaleHeart Valve DiseasesHeart VentriclesHumansMitral Valve InsufficiencyMitral Valve ProlapseRupture

Identifiers

PMID30470812
PMCPMC6251907
OpenAlexW2901461885

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.