ReviewJournal of exposure science & environmental epidemiology2019
A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects.
Review in Journal of exposure science & environmental epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07391397 (Reducing Rural Health Disparities by Empowering People to Minimize PFAS Exposure and Improve Cardiovascular Health), which is not on this map. Cited by 858 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Rural Health Disparities by Empowering People to Minimize PFAS Exposure and Improve Cardiovascular Health
Who cites it
858 citing papers in PubMed, 2,478 citations in OpenAlex.
- Supporting informed decisions about breast cancer screening in communities with known environmental contamination: a pre-post study.Cancer causes & control : CCC · 2025Trial
- Per- and polyfluoroalkyl substances in commercially important marine species of fish and shellfish from Alaska and implications for human exposure.Toxicology reports · 2026Article
- Association between PFAS and renal function indicators in cord blood of newborns: modifying effects of newborn sex and maternal factors.Annals of medicine · 2026Article
- Comparative evaluation of pre-column derivatization strategies for PFAS analysis in paper-based food contact material using GC-MS.Analytical and bioanalytical chemistry · 2026Article
- Deciphering the Role of Energy Transfer Configuration in PFAS Recognition by Metal-Organic Frameworks.Angewandte Chemie (International ed. in English) · 2026Article
- PFAS exposure in 12-year-old children and its association with metabolic markers.Pediatric research · 2026Article
- Titanium-Catalyzed Defluorination of Poly(Vinyl Fluoride) and Poly(Vinylidene Fluoride) Under Friedel-Crafts Conditions.Angewandte Chemie (International ed. in English) · 2026Article
- Associations of Serum Per- and Polyfluoroalkyl Substances (PFAS) With Epigenetic Age and DNA Methylation in US Airport Firefighters.Environmental and molecular mutagenesis · 2026Article
- MALDI mass spectrometry imaging across spatial scales in toxicology: tissue evidence, cellular heterogeneity, and emerging single-cell opportunities.Analytical and bioanalytical chemistry · 2026Review
- Perfluorooctanoic acid exposure disrupts gut microbiota and aggravates experimental colitis.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Beyond genetics: how environmental stressors drive pediatric hypertension risk.Pediatric nephrology (Berlin, Germany) · 2026Review
- Dietary and social predictors of PFAS exposure in Hispanic children from Northern Virginia.Journal of exposure science & environmental epidemiology · 2026Article
- Better Together Than Apart: Degradation of Emerging Contaminants in Concentrated Streams Using UV/Sulfite/Iodide and UV/Hydrogen Peroxide Treatment Trains.ACS environmental Au · 2026Article
- Ultrashort-Chain and Short-Chain Per- and Polyfluoroalkyl Substances Are Universal Contaminants in Wines: A Comprehensive Survey of Red, White, Rosé, and Sparkling Samples.Journal of xenobiotics · 2026Article
- Dietary folate, vitamin D, and inflammation modify associations between prenatal per- and polyfluoroalkyl substance (PFAS) exposures and fetal growth.Nutrition and health · 2026Article
- From Follicle Development to Fertilization: How PCBs and PFAS May Shape Female Reproductive Health.Toxics · 2026Review
- Association between seafood consumption and serum polyfluoroalkyl substance concentrations among Korean adolescents: the Korean National Environmental Health Survey (KoNEHS) cycle 5, 2021-2023.Annals of occupational and environmental medicine · 2026Article
- Per- and Polyfluoroalkyl Substances (PFAS) Exposure Profiles and Their Predictors in a Study of US Volunteer Firefighters.American journal of industrial medicine · 2026Article
- Artificial Intelligence-Powered One Health: A Predictive Framework for Managing Persistent Chemical Threats across Human, Animal, and Environmental Systems.Global challenges (Hoboken, NJ) · 2026Review
- Chemical Food Safety of Edible Insects in the European Union: Current Evidence and Regulatory Blind Spots.Toxics · 2026Review
798 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Here, we review present understanding of sources and trends in human exposure to poly- and perfluoroalkyl substances (PFASs) and epidemiologic evidence for impacts on cancer, immune function, metabolic outcomes, and neurodevelopment. More than 4000 PFASs have been manufactured by humans and hundreds have been detected in environmental samples. Direct exposures due to use in products can be quickly phased out by shifts in chemical production but exposures driven by PFAS accumulation in the ocean and marine food chains and contamination of groundwater persist over long timescales. Serum concentrations of legacy PFASs in humans are declining globally but total exposures to newer PFASs and precursor compounds have not been well characterized. Human exposures to legacy PFASs from seafood and drinking water are stable or increasing in many regions, suggesting observed declines reflect phase-outs in legacy PFAS use in consumer products. Many regions globally are continuing to discover PFAS contaminated sites from aqueous film forming foam (AFFF) use, particularly next to airports and military bases. Exposures from food packaging and indoor environments are uncertain due to a rapidly changing chemical landscape where legacy PFASs have been replaced by diverse precursors and custom molecules that are difficult to detect. Multiple studies find significant associations between PFAS exposure and adverse immune outcomes in children. Dyslipidemia is the strongest metabolic outcome associated with PFAS exposure. Evidence for cancer is limited to manufacturing locations with extremely high exposures and insufficient data are available to characterize impacts of PFAS exposures on neurodevelopment. Preliminary evidence suggests significant health effects associated with exposures to emerging PFASs. Lessons learned from legacy PFASs indicate that limited data should not be used as a justification to delay risk mitigation actions for replacement PFASs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.