ReviewNature reviews. Urology2019
Current insights into the mechanisms and management of infection stones.
Review in Nature reviews. Urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Schistosomiasis-Microbiota Interactions: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2024Pooled it
- Pooled it
- Metabolic changes in kidney stone disease.Frontiers in immunology · 2023Pooled it
- Association of Kidney Stones and Recurrent UTIs: the Chicken and Egg Situation. A Systematic Review of Literature.Current urology reports · 2022Pooled it
- A retrospective study using machine learning to develop predictive model to identify urinary infection stones in vivo.Urolithiasis · 2023Trial
- A comparative analysis of metabolic and urinary bacterial culture profiles between patients with staghorn and non-staghorn infectious renal stones.BMC nephrology · 2026Article
- Sex Differences in Admission Urine Culture Positivity, Pathogen Distribution, and Clinical Characteristics Among Patients with Calcium Oxalate Stones.Pathogens (Basel, Switzerland) · 2026Article
- Urolithiasis in patients with cancer.Nature reviews. Urology · 2026Review
- A study on metabolic differences between infectious and non-infectious stones in patients with urine culture positive for Proteus mirabilis.BMC urology · 2026Article
- The Role of Copper in Struvite Formation in the Context of Infection Urinary Stones: A Journey at the Interface of Physics, Chemistry and Microbiology.Molecules (Basel, Switzerland) · 2026Article
- Rapid and accurate preoperative diagnosis of urinary tract infections in urolithiasis patients: clinical validation of the HB&L system.BMC infectious diseases · 2026Article
- Research advances on the urinary microbiome in non-infectious urinary tract diseases: from community composition to clinical prospects.Frontiers in cellular and infection microbiology · 2026Review
- Bacteriological Analysis of Urine Cultures and Related Clinical Features in Patients with Infection Stones: A Single-Center Retrospective Cohort Analysis from Beijing, China.Infection and drug resistance · 2026Article
- Urinary tract infection in urolithiasis patients: risk factor analysis, pathogen distribution, and antimicrobial resistance characteristics.Frontiers in public health · 2026Article
- Role of UropathogenicPathogens (Basel, Switzerland) · 2025Review
- Metabolic abnormalities in pure vs. mixed struvite stone formers: A retrospective comparative analysis utilising large language models for data extraction.BJUI compass · 2025Article
- Safety and efficacy of flexible and navigable suction combined with retrograde flexible ureteroscopy in the management of infectious stones.BMC infectious diseases · 2025Article
- Acid excretion is impaired in calcium oxalate stone formers.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Does a kidney stone culture make sense? The findings of microbiological cultures of kidney stones and correlation with stone composition, preoperative urine testing and postoperative SIRS.World journal of urology · 2025Article
- Effect of long-term postoperative OM-89 administration on bacteriuria from suspected infectious stones.Investigative and clinical urology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection stones are complex aggregates of crystals amalgamated in an organic matrix that are strictly associated with urinary tract infections. The management of patients who form infection stones is challenging owing to the complexity of the calculi and high recurrence rates. The formation of infection stones is a multifactorial process that can be driven by urine chemistry, the urine microenvironment, the presence of modulator substances in urine, associations with bacteria, and the development of biofilms. Despite decades of investigation, the mechanisms of infection stone formation are still poorly understood. A mechanistic understanding of the formation and growth of infection stones - including the role of organics in the stone matrix, microorganisms, and biofilms in stone formation and their effect on stone characteristics - and the medical implications of these insights might be crucial for the development of improved treatments. Tools and approaches used in various disciplines (for example, engineering, chemistry, mineralogy, and microbiology) can be applied to further understand the microorganism-mineral interactions that lead to infection stone formation. Thus, the use of integrated multidisciplinary approaches is imperative to improve the diagnosis, prevention, and treatment of infection stones.
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