Evidence map›Paper›PMID 30470779›Full record

ArticleScientific reports2018

Feature Ranking in Predictive Models for Hospital-Acquired Acute Kidney Injury.

Lijuan Wu, Yong Hu, Xiaoxiao Liu, Xiangzhou Zhang, Weiqi Chen, Alan S L Yu, John A Kellum, Lemuel R Waitman, Mei Liu

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lijuan WuBig Data Decision Institute (BDDI), Jinan University, Guangzhou, 510632, China.
Yong HuBig Data Decision Institute (BDDI), Jinan University, Guangzhou, 510632, China. henryhu200211@163.com.
Xiaoxiao LiuBig Data Decision Institute (BDDI), Jinan University, Guangzhou, 510632, China.
Xiangzhou ZhangBig Data Decision Institute (BDDI), Jinan University, Guangzhou, 510632, China.ORCID http://orcid.org/0000-0003-3752-0045
Weiqi ChenBig Data Decision Institute (BDDI), Jinan University, Guangzhou, 510632, China.
Alan S L YuDivision of Nephrology and Hypertension and the Kidney Institute, University of Kansas Medical Center, Kansas City, 66160, USA.ORCID http://orcid.org/0000-0002-1776-2533
John A KellumCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, 15260, USA.
Lemuel R WaitmanDepartment of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, Kansas City, 66160, USA.
Mei LiuDepartment of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, Kansas City, 66160, USA. meiliu@kumc.edu.

Funding

RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
Heartland Institute for Clinical and Translational ResearchUL1TR000001 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2012 to 2015
$13.0M
Guangdong Science and Technology Department (Science and Technology Department, Guangdong Province) 2017B030308008National Natural Science Foundation of China (National Science Foundation of China) 91746204NCATS NIH HHS UL1 TR000001NCATS NIH HHS UL1 TR002366
6 · The paper itself

Abstract

Acute Kidney Injury (AKI) is a common complication encountered among hospitalized patients, imposing significantly increased cost, morbidity, and mortality. Early prediction of AKI has profound clinical implications because currently no treatment exists for AKI once it develops. Feature selection (FS) is an essential process for building accurate and interpretable prediction models, but to our best knowledge no study has investigated the robustness and applicability of such selection process for AKI. In this study, we compared eight widely-applied FS methods for AKI prediction using nine-years of electronic medical records (EMR) and examined heterogeneity in feature rankings produced by the methods. FS methods were compared in terms of stability with respect to data sampling variation, similarity between selection results, and AKI prediction performance. Prediction accuracy did not intrinsically guarantee the feature ranking stability. Across different FS methods, the prediction performance did not change significantly, while the importance rankings of features were quite different. A positive correlation was observed between the complexity of suitable FS method and sample size. This study provides several practical implications, including recognizing the importance of feature stability as it is desirable for model reproducibility, identifying important AKI risk factors for further investigation, and facilitating early prediction of AKI.

Indexed as

Models, StatisticalSeverity of Illness IndexAcute Kidney InjuryAdolescentAdultElectronic Health RecordsFemaleHospitalsHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentYoung Adult

Identifiers

PMID30470779
PMCPMC6251919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.