ArticleScientific reports2018
Adolescent conditioning affects rate of adult fear, safety and reward learning during discriminative conditioning.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Second-order conditioning of safety in male and female rats.Behavioural brain research · 2026Article
- Safety learning during adolescence facilitates fear regulation in adult mice.Developmental cognitive neuroscience · 2025Article
- PTSD symptoms moderate predictors of psychophysiological arousal during fear inhibition: Evidence from a fear, reward, and neutral discrimination task.Journal of affective disorders · 2025Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- Conditioned inhibition of fear and reward in male and female rats.Neurobiology of learning and memory · 2024Article
- Psychological and physiological correlates of stimulus discrimination in adults.Psychophysiology · 2023Article
- Encoding of conditioned inhibitors of fear in the infralimbic cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Interaction of stress and alcohol on discriminating fear from safety and reward in male and female rats.Psychopharmacology · 2023Article
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Juvenile stress facilitates safety learning in male and female high alcohol preferring mice.Behavioural brain research · 2021Article
- On the basis of sex: Differences in safety discrimination vs. conditioned inhibition.Behavioural brain research · 2021Review
- Pre-adolescent stress disrupts adult, but not adolescent, safety learning.Behavioural brain research · 2021Article
- Article
- Assaying Fear Memory Discrimination and Generalization: Methods and Concepts.Current protocols in neuroscience · 2020Article
- Know safety, no fear.Neuroscience and biobehavioral reviews · 2020Review
- Sex differences in fear regulation and reward-seeking behaviors in a fear-safety-reward discrimination task.Behavioural brain research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Fear and reward memories formed in adulthood are influenced by prior experiences. Experiences that occur during sensitive periods, such as adolescence, can have an especially high impact on later learning. Fear and reward memories form when aversive or appetitive events co-occur with initially neutral stimuli, that then gain negative or positive emotional load. Fear and reward seeking behaviours are influenced by safety cues, signalling the non-occurrence of a threat. It is unclear how adolescent fear or reward pre-conditioning influences later dynamics of these conditioned emotions, and conditioned safety. In this study, we presented male rats with adolescent fear or reward pre-conditioning, followed by discriminative conditioning in adulthood. In this discriminative task, rats are simultaneously conditioned to reward, fear and safety cues. We show that adolescent reward pre-conditioning did not affect the rate of adult reward conditioning, but instead accelerated adult safety conditioning. Adolescent fear pre-conditioning accelerated adult fear and reward seeking behaviours but delayed adult safety expression. Together, our results suggest that the dynamics of safety conditioning can be influenced by adolescent priming of different valences. Taking adolescent experiences into consideration can have implications on how we approach therapy options for later learned fear disorders where safety learning is compromised.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.