ArticleNature communications2018
Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.
- Emerging roles of ATG7 in human health and disease.EMBO molecular medicine · 2021Pooled it
- Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes.The FEBS journal · 2026Article
- A Hepatocyte-to-Stellate Cell Axis Couples Alternate-Day Fasting to Liver Fibrosis Resolution via ATG7 S-Nitrosylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 17β-Estradiol Modulates Cancer Cell-Fibroblast Communication via Autophagy-Mediated Extracellular Vesicle Secretion and Promotes Poor Prognosis in Non-Small Cell Lung Cancer.International journal of molecular sciences · 2026Article
- Next-Generation Hepatocyte Expansion: Bridging Molecular Reprogramming with Multicellular Organoids for Clinical Translation.Stem cell reviews and reports · 2026Review
- Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review).International journal of molecular medicine · 2026Review
- Plant-Derived Polyphenols in Cancer Therapy: Bridging Molecular Mechanisms and Bioavailability Toward Clinical Translation.Pharmaceutics · 2026Review
- Flavonoids as Dual Topoisomerase I and II Inhibitors: Mechanistic Insights and Emerging Anticancer Strategies.Chemistry & biodiversity · 2026Review
- Unraveling key molecules mediating the mechanisms of YAP deletion or inhibition in liver fibrosis regression through a multi-omics approach.Histology and histopathology · 2026Article
- Article
- Post-translational modifications in hepatocellular carcinoma: mechanisms and therapeutic potential.Medical oncology (Northwood, London, England) · 2025Review
- Integrative multiomic and immune profiling of lung adenocarcinoma: molecular landscapes, gene expression, and treatment response insights.The oncologist · 2025Article
- Autophagy-Targeting Nanomedicine: Strike at the Heart of the Cancer via Precise Modulation of Autophagy.Exploration (Beijing, China) · 2025Review
- Exosomes derived from 3D-cultured hUCMSCs exhibit superior hepatoprotection against ALF.iScience · 2025Article
- Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases.Journal of Zhejiang University. Science. B · 2025Review
- Targeting Lipophagy in Liver Diseases: Impact on Oxidative Stress and Steatohepatitis.Antioxidants (Basel, Switzerland) · 2025Review
- Liver Metabolism at the Crossroads: The Reciprocal Control of Nutrient-Sensing Nuclear Receptors and Autophagy.International journal of molecular sciences · 2025Review
- SNRK tames mTOR against metabolic dysfunction-associated steatotic liver disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- NETs-related genes predict prognosis and are correlated with the immune microenvironment in osteosarcoma.Frontiers in oncology · 2025Article
- Autophagy related 14 protects against liver injury by inhibiting multiple cell death pathways.eGastroenterology · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 10 institutions in 4 countries.
Youngmin A LeeDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ylee04@rockefeller.edu.
Luke A NoonDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Kemal M AkatLaboratory of RNA Molecular Biology, Rockefeller University, New York, NY, 10065, USA.
Maria D YbanezDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ting-Fang LeeDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Marie-Luise BerresDepartment of Internal Medicine III, University Hospital RWTH Aachen, 52074, Aachen, Germany.
Naoto FujiwaraDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nicolas GoossensDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Hsin-I ChouDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Fatemeh P Parvin-NejadDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Bilon KhambuDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Elisabeth G M KramerDepartment of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ronald GordonDepartment for Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Cathie PflegerDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Doris GermainDepartment of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Gareth R JohnDepartment of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Kirk N CampbellDivision of Nephrology, Icahn School of Medicine at Mount Sinai, NY, 10029, New York, USA.
Zhenyu YueDepartment of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Xiao-Ming YinDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Ana Maria CuervoDepartment of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.ORCID http://orcid.org/0000-0002-0771-700X
Mark J CzajaDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, GA 30307, USA.
M Isabel FielDepartment for Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Yujin HoshidaDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0001-9430-1426
Scott L FriedmanDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0003-1178-6195
Icahn School of Medicine at Mount Sinai · USAllen Institute for Brain Science · USIndiana University School of MedicineRockefeller University · USThe University of Texas Southwestern Medical Center · USAlbert Einstein College of Medicine · USCentro de Investigacion Principe Felipe · ESEmory University · USRWTH Aachen University · DEUniversity Hospital of Geneva · CH
Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MRole of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MACIAN, FERNANDO · 2009 to 2024
$36.2MTHE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson · 2015 to 2026
$35.4MEinstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8MMODULATION OF ACUTE TOXIC LIVER INJURYR01DK044234 · NIDDK · YESHIVA UNIVERSITY · PI SRINIVASAN, SHANTHI K · 1992 to 2023
$7.6MThe Role of KLF6 in Hepatic FibrosisR01DK056621 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FRIEDMAN, SCOTT L. · 2000 to 2019
$6.2MDecreased Protein Degradation in AgingR37AG021904 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2013 to 2022
$4.4MMount Sinai Nephrology Research Training GrantT32DK007757 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CAMPBELL, KIRK N, HE, JOHN CIJIANG · 1998 to 2022
$3.8MMolecular Prognostic Indicators in Liver Cirrhosis and CancerR01DK099558 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HOSHIDA, YUJIN · 2013 to 2016
$2.6MThe role of dendrin in glomerular disease progressionR01DK103022 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAMPBELL, KIRK N · 2015 to 2019
$1.9MAutophagy during hepatic stellate cell activation in alcoholic liver injuryR01AA020709 · NIAAA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDMAN, SCOTT L. · 2011 to 2015
$1.8MRabex-5 regulation of Ras and Notch signaling in development and diseaseR01GM122995 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PFLEGER, CATHIE M · 2017 to 2020
$1.3MEuropean Research Council 671231NCATS NIH HHS UL1 TR001866NCI NIH HHS P30 CA196521NIAAA NIH HHS R01 AA020709NIA NIH HHS P30 AG038072NIA NIH HHS R37 AG021904NIDDK NIH HHS R01 DK044234NIDDK NIH HHS R01 DK056621NIDDK NIH HHS R01 DK099558NIDDK NIH HHS R01 DK103022NIDDK NIH HHS R56 DK044234NIDDK NIH HHS T32 DK007757NIGMS NIH HHS R01 GM122995
Abstract
Activation of the Hippo pathway effector Yap underlies many liver cancers, however no germline or somatic mutations have been identified. Autophagy maintains essential metabolic functions of the liver, and autophagy-deficient murine models develop benign adenomas and hepatomegaly, which have been attributed to activation of the p62/Sqstm1-Nrf2 axis. Here, we show that Yap is an autophagy substrate and mediator of tissue remodeling and hepatocarcinogenesis independent of the p62/Sqstm1-Nrf2 axis. Hepatocyte-specific deletion of Atg7 promotes liver size, fibrosis, progenitor cell expansion, and hepatocarcinogenesis, which is rescued by concurrent deletion of Yap. Our results shed new light on mechanisms of Yap degradation and the sequence of events that follow disruption of autophagy, which is impaired in chronic liver disease.
Indexed as
AutophagyAdaptor Proteins, Signal TransducingAnimalsAutophagy-Related Protein 7CarcinogenesisCell Cycle ProteinsCell DifferentiationFemaleHepatocytesHumansLiverLiver NeoplasmsMaleMicePhosphoproteinsProteolysisAdaptor Proteins, Signal TransducingAutophagy-Related Protein 7Cell Cycle ProteinsPhosphoproteinsTranscription FactorsYAP1 protein, humanYap1 protein, mouseYAP-Signaling Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.