Evidence map›Paper›PMID 30470711›Full record

ArticleThe Journal of cell biology2019

Single event visualization of unconventional secretion of FGF2.

Eleni Dimou, Katia Cosentino, Evgenia Platonova, Uris Ros, Mohsen Sadeghi, Purba Kashyap, Taxiarchis Katsinelos, Sabine Wegehingel, Frank Noé, Ana J García-Sáez and 2 more

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In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Eleni DimouHeidelberg University Biochemistry Center, Heidelberg, Germany.ORCID 0000-0003-4885-135X
Katia CosentinoInterfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen, Germany.
Evgenia PlatonovaRandall Division of Cell and Molecular Biophysics, King's College London, London, UK.
Uris RosInterfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen, Germany.
Mohsen SadeghiDepartment of Mathematics and Computer Science, Free University Berlin, Berlin, Germany.ORCID 0000-0002-7698-5630
Purba KashyapInstitute for Chemistry and Biochemistry, Free University Berlin, Berlin, Germany.ORCID 0000-0002-4620-8814
Taxiarchis KatsinelosHeidelberg University Biochemistry Center, Heidelberg, Germany.ORCID 0000-0001-6951-3216
Sabine WegehingelHeidelberg University Biochemistry Center, Heidelberg, Germany.
Frank NoéDepartment of Mathematics and Computer Science, Free University Berlin, Berlin, Germany.ORCID 0000-0003-4169-9324
Ana J García-SáezInterfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen, Germany.ORCID 0000-0002-3894-5945
Helge EwersRandall Division of Cell and Molecular Biophysics, King's College London, London, UK helge.ewers@fu-berlin.de.ORCID 0000-0003-3948-4332
Walter NickelHeidelberg University Biochemistry Center, Heidelberg, Germany walter.nickel@bzh.uni-heidelberg.de.ORCID 0000-0002-6496-8286
Heidelberg University · DEFreie Universität Berlin · DEUniversity of Tübingen · DEKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FGF2 is exported from cells by an unconventional secretory mechanism. Here, we directly visualized individual FGF2 membrane translocation events at the plasma membrane using live cell TIRF microscopy. This process was dependent on both PI(4,5)P

Indexed as

AnimalsCell MembraneCHO CellsCricetulusFibroblast Growth Factor 2HEK293 CellsHeparan SulfateHumansKineticsMicroscopy, FluorescenceModels, BiologicalPhosphatidylinositol 4,5-DiphosphateProtein MultimerizationProtein TransportSecretory PathwayFibroblast Growth Factor 2Heparan SulfatePhosphatidylinositol 4,5-Diphosphate

Identifiers

PMID30470711
PMCPMC6363455
OpenAlexW2901809796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.