Observational studyHeart & lung : the journal of critical care
Markers of cardiogenic shock predict persistent acute kidney injury after out of hospital cardiac arrest.
Observational study in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial.BMC cardiovascular disorders · 2022Trial
- Kidney injury in patients with heart failure-related cardiogenic shock: Results from an international, multicentre cohort study.European journal of heart failure · 2025Article
- Acute Kidney Injury in Patients After Cardiac Arrest: Effects of Targeted Temperature Management.Life (Basel, Switzerland) · 2025Article
- EPOS-OHCA: Early Predictors of Outcome and Survival after non-traumatic Out-of-Hospital Cardiac Arrest.Resuscitation plus · 2024Article
- Role of platelet to albumin ratio for predicting persistent acute kidney injury in patients admitted to the intensive care unit.BMC anesthesiology · 2023Article
- National outcomes of urgent vs. non-urgent percutaneous edge-to-edge transcatheter mitral valve repair.International journal of cardiology. Heart & vasculature · 2022Article
- Renal Injuries after Cardiac Arrest: A Morphological Ultrastructural Study.International journal of molecular sciences · 2022Article
- Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance.Disease markers · 2022Article
- Cardiogenic shock and acute kidney injury: the rule rather than the exception.Heart failure reviews · 2021Review
- The adaptive immune response in cardiac arrest resuscitation induced ischemia reperfusion renal injury.Journal of biological research (Thessalonike, Greece) · 2020Article
- Sepsis-Associated Acute Kidney Disease.Kidney international reports · 2020Article
- Renal function after out-of-hospital cardiac arrest; the influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial.Critical care (London, England) · 2019Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveIschemia and reperfusion injury (IRI) in cardiac arrest patients after return to spontaneous circulation causes dysfunctions in multiple organs. Kidney injury is generally transient but in some patients persists and contributes both to mortality and increased resource utilisation. Ongoing shock may compound renal injury from IRI, resulting in persistent dysfunction. We tested whether cardiac dysfunction was associated with the development of persistent acute kidney injury (PAKI) in the first 72 h after cardiac arrest.
methodsWe performed an observational retrospective study from January 2013 to April 2017. We included consecutive patients treated after out-of-hospital cardiac arrest at a single academic medical center with renal function measured and immediately and for 48 h post arrest. We also recorded each patient's pre arrest baseline creatinine, demographic and clinical characteristics. Our primary outcome of interest was PAKI, defined as acute kidney injury (AKI) on at least 2 measurements 24 h apart. We compared demographics and outcomes between patients with PAKI and those without, and used logistic regression to identify independent predictors of PAKI.
resultsOf 98 consecutive patients, we excluded 24 for missing data. AKI was present in 75% of subjects on arrival. PAKI developed in 35% of patients. PAKI patients had a longer hospital length of stay (median 21 vs 11 days) and lower hospital survival (47% vs 71%). Serum lactate levels, dosage of adrenaline during resuscitation and days of dobutamine infusion strongly predicted PAKI.
conclusionsAmong patient who survive cardiac arrest, acute AKI is common and PAKI occurs in more than one third. PAKI is associated both with survival and with length of stay at the hospital. High doses of adrenaline, high serial serum lactate levels, and dose of dobutamine predict PAKI. Evaluation of the trajectory of renal function over the first few days after resuscitation can provide prognostic information about patient recovery.
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