ReviewAlcohol (Fayetteville, N.Y.)2019
Leveraging calcium imaging to illuminate circuit dysfunction in addiction.
Review in Alcohol (Fayetteville, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 58 citations in OpenAlex.
- Intranasal cocaine self-administration in male mice.Nature communications · 2025Article
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Fiber Photometry Analysis of Spontaneous Dopamine Signals: TheACS chemical neuroscience · 2025Article
- PASTa: An Open-Source Analysis and Signal Processing Toolbox for Fiber Photometry Data.Current protocols · 2025Article
- Recurrent activity propagates through labile ensembles in macaque dorsolateral prefrontal microcircuits.Current biology : CB · 2025Article
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Review of cocaine-induced brain vascular and cellular function changes measuredNeurophotonics · 2025Review
- Role of Neural Circuits in Cognitive Impairment.Neurochemical research · 2024Review
- Fiber photometry in neuroscience research: principles, applications, and future directions.Pharmacological reports : PR · 2024Review
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.Current biology : CB · 2024Article
- Changes in dorsomedial striatum activity during expression of goal-directed vs. habit-like cue-induced cocaine seeking.Addiction neuroscience · 2024Article
- Space wandering in the rodent default mode network.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.bioRxiv : the preprint server for biology · 2024Article
- A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging.Neuropharmacology · 2024Article
- Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice.Neuropharmacology · 2024Article
- Imaging distinct neuronal populations with a dual channel miniscope.Frontiers in neuroscience · 2024Article
- Review
- Calcium imaging: a technique to monitor calcium dynamics in biological systems.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Sexual differentiation of neural mechanisms of stress sensitivity during puberty.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Non-Consummatory Behavior Signals Predict Aversion-Resistant Alcohol Drinking in Head-Fixed Mice.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Alcohol and drug use can dysregulate neural circuit function to produce a wide range of neuropsychiatric disorders, including addiction. To understand the neural circuit computations that mediate behavior, and how substances of abuse may transform them, we must first be able to observe the activity of circuits. While many techniques have been utilized to measure activity in specific brain regions, these regions are made up of heterogeneous sub-populations, and assessing activity from neuronal populations of interest has been an ongoing challenge. To fully understand how neural circuits mediate addiction-related behavior, we must be able to reveal the cellular granularity within brain regions and circuits by overlaying functional information with the genetic and anatomical identity of the cells involved. The development of genetically encoded calcium indicators, which can be targeted to populations of interest, allows for in vivo visualization of calcium dynamics, a proxy for neuronal activity, thus providing an avenue for real-time assessment of activity in genetically and anatomically defined populations during behavior. Here, we highlight recent advances in calcium imaging technology, compare the current technology with other state-of-the-art approaches for in vivo monitoring of neural activity, and discuss the strengths, limitations, and practical concerns for observing neural circuit activity in preclinical addiction models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.