Evidence map›Paper›PMID 30470507›Full record

ArticleDNA repair2019

The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations.

Jie Chen, Xinggui Shen, Sibile Pardue, Andrew T Meram, Saranya Rajendran, Ghali E Ghali, Christopher G Kevil, Rodney E Shackelford

Open access · greenAbstract read
In one paragraph

Article in DNA repair, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. DNA damage targeted therapy for advanced breast cancer.Exploration of targeted anti-tumor therapy · 2024
    Review
  4. Article
  5. Review
  6. Hydrogen Sulfide Biology and Its Role in Cancer.Molecules (Basel, Switzerland) · 2022
    Review
  7. Review
  8. Molecular Functions of Hydrogen Sulfide in Cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jie ChenDepartment of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, Louisiana, 71130, United States.
Xinggui ShenDepartment of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, Louisiana, 71130, United States.
Sibile PardueDepartment of Cell Biology & Anatomy, LSU Health Sciences Center Shreveport, Shreveport, Louisiana, 71130, United States.
Andrew T MeramHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, United States.
Saranya RajendranDepartment of Cell Biology & Anatomy, LSU Health Sciences Center Shreveport, Shreveport, Louisiana, 71130, United States.
Ghali E GhaliHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, United States.
Christopher G KevilDepartment of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, Louisiana, 71130, United States; Department of Cell Biology & Anatomy, LSU Health Sciences Center Shreveport, Shreveport, Louisiana, 71130, United States. Electronic address: CKevil@lsuhsc.edu.
Rodney E ShackelfordDepartment of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, Louisiana, 71130, United States. Electronic address: rshack@lsuhsc.edu.
Louisiana State University Health Sciences Center Shreveport · US

Funding

Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6M
Hydrogen sulfide and vascular remodelingR01HL113303 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI KEVIL, CHRISTOPHER G · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL113303NIGMS NIH HHS P20 GM121307
6 · The paper itself

Abstract

The ataxia telangiectasia-mutated and Rad3-related (ATR) serine/threonine kinase plays a central role in the repair of replication-associated DNA damage, the maintenance of S and G2/M-phase genomic stability, and the promotion of faithful mitotic chromosomal segregation. A number of stimuli activate ATR, including persistent single-stranded DNA at stalled replication folks, R loop formation, hypoxia, ultraviolet light, and oxidative stress, leading to ATR-mediated protein phosphorylation. Recently, hydrogen sulfide (H

Indexed as

Ataxia Telangiectasia Mutated ProteinsCell Line, TumorCystathionine beta-SynthaseCystathionine gamma-LyaseDNA Breaks, Double-StrandedGene Expression RegulationHumansHydrogen SulfideMutationPhosphorylationRNA, MessengerSulfurtransferases3-mercaptopyruvate sulphurtransferaseAtaxia Telangiectasia Mutated ProteinsATR protein, humanCystathionine beta-SynthaseCystathionine gamma-LyaseHydrogen SulfideRNA, MessengerSulfurtransferases3-Mercaptopyruvate sulfurtransferaseATRCHK1Cystathionine-β-synthaseCystathionine γ-lyaseH(2)SHydrogen sulfideNicotinamidephosphoribosyltransferase

Identifiers

PMID30470507
PMCPMC6925466
OpenAlexW2901907626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.