ReviewMolecules (Basel, Switzerland)2018
Selenium, Selenoproteins, and Female Reproduction: A Review.
Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Association of celiac disease with menstrual and hormonal disturbances: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2026Pooled it
- The Role of Selenium During Gestation in the Development of Fetal Congenital Anomalies: A Systematic Review.Nutrients · 2026Pooled it
- Relation between Selenium and Female Fertility: A Systematic Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Pooled it
- A Multicountry Analysis of Maternal Selenium Status in Pregnancy and Lactation and Infant Birth Outcomes: Findings from the Women First Maternal Preconception Study.The Journal of nutrition · 2026Trial
- The Effects of Microplastics and Trace Elements on Ovarian Function and Pathology: A Literature Review.International journal of molecular sciences · 2026Review
- Effect of Sodium Selenite and Hydroxy-Selenomethionine Supplementation in Hanwoo Cows on Reproductive Performance and Growth Performance of Their Offspring.Animals : an open access journal from MDPI · 2026Article
- Serum trace and heavy metal exposure and IVF/ICSI outcomes: modifying effects of maternal diet in a prospective cohort.Reproductive biology and endocrinology : RB&E · 2026Article
- Impact of Nutrition on Embryo Production in Cattle: Mechanistic Insights.Animals : an open access journal from MDPI · 2026Review
- Role of selenium in cow fertility and reproduction-A review.Veterinary research communications · 2026Review
- Case Report: Infertility in bitches at a German Shepherd breeding center and nutritional management.Frontiers in veterinary science · 2026Article
- Dietary Selenium-Enriched Aquatic Products for Human Health.Nutrients · 2025Review
- Selenium nanoparticles mitigate Cyclophosphamide-Induced premature ovarian failures in mice by activating PI3K/AKT signaling pathway and inhibiting ferroptosis.Journal of ovarian research · 2025Article
- Selenium as a Modulator of Reproductive Immunity: Molecular Insights and Translational Potential in Livestock.Reproduction in domestic animals = Zuchthygiene · 2025Review
- Effect of trace mineral injection on serum trace mineral concentrations and reproductive indicators in sheep synchronised during the anoestrus period.Veterinarni medicina · 2025Article
- Evaluation of gibberellic acid toxicity on pre and postnatal ovarian development and potential protective effect of selenium in albino rats: histological, immunohistochemical, and biochemical study.Anatomy & cell biology · 2025Article
- Integrated chemical exposome-metabolome profiling of follicular fluid and associations with fertility outcomes during assisted reproduction.Environment international · 2025Article
- Associations of Essential and Non-Essential Trace Elements' Levels in the Blood, Serum, and Urine in Women with Premature Ovarian Insufficiency.Biological trace element research · 2025Article
- Selenium + Vitamin E Supplementation in Anestrus Goats: A Strategy to Enhance Reproductive Outcomes Under a Semi-Arid Production System.Animals : an open access journal from MDPI · 2025Article
- Hydroxy-selenomethionine helps cows to overcome heat stress by enhancing antioxidant capacity and alleviating blood-milk barrier damage.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Single-cell transcriptomics reveals the multidimensional dynamic heterogeneity from primary to metastatic gastric cancer.iScience · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
Selenium (Se) is an essential micronutrient that has several important functions in animal and human health. The biological functions of Se are carried out by selenoproteins (encoded by twenty-five genes in human and twenty-four in mice), which are reportedly present in all three domains of life. As a component of selenoproteins, Se has structural and enzymatic functions; in the latter context it is best recognized for its catalytic and antioxidant activities. In this review, we highlight the biological functions of Se and selenoproteins followed by an elaborated review of the relationship between Se and female reproductive function. Data pertaining to Se status and female fertility and reproduction are sparse, with most such studies focusing on the role of Se in pregnancy. Only recently has some light been shed on its potential role in ovarian physiology. The exact underlying molecular and biochemical mechanisms through which Se or selenoproteins modulate female reproduction are largely unknown; their role in human pregnancy and related complications is not yet sufficiently understood. Properly powered, randomized, controlled trials (intervention vs. control) in populations of relatively low Se status will be essential to clarify their role. In the meantime, studies elucidating the potential effect of Se supplementation and selenoproteins (i.e., GPX1, SELENOP, and SELENOS) in ovarian function and overall female reproductive efficiency would be of great value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.