Evidence map›Paper›PMID 30469507›Full record

ArticleMarine drugs2018

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models.

Elena V Kryukova, Igor A Ivanov, Dmitry S Lebedev, Ekaterina N Spirova, Natalia S Egorova, Marios Zouridakis, Igor E Kasheverov, Socrates J Tzartos, Victor I Tsetlin

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Elena V KryukovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. evkr@mail.ru.
Igor A IvanovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. chai.mail0@gmail.com.
Dmitry S LebedevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. dmitry-1@bk.ru.
Ekaterina N SpirovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. katya_spirova@mail.ru.
Natalia S EgorovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. natalyegorov@yandex.ru.
Marios ZouridakisDepartment of Neurobiology, Hellenic Pasteur Institute, 127, Vas. Sofias ave., Athens 115 21, Greece. marzouri@gmail.com.
Igor E KasheverovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. shak_ever@yahoo.com.
Socrates J TzartosDepartment of Neurobiology, Hellenic Pasteur Institute, 127, Vas. Sofias ave., Athens 115 21, Greece. stzartos@gmail.com.
Victor I TsetlinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. vits@mx.ibch.ru.
Institute of Bioorganic Chemistry · RUPasteur Hellenic Institute · GRSechenov University · RU

Funding

Russian Foundation for Basic Research 17-00-00063 komfiRussian Foundation for Basic Research 18-04-00844Russian Foundation for Basic Research 18-04-01366
6 · The paper itself

Abstract

α-Conotoxins from

Indexed as

Conus SnailAllosteric SiteAnalgesicsAnimalsConotoxinsDrug DesignInhibitory Concentration 50Nicotinic AntagonistsOocytesRadioligand AssayReceptors, NicotinicXenopus laevisalpha-conotoxin, Conus generalisAnalgesicsconotoxin alpha-RgIA, Conus regiusConotoxinsnAChR alpha9Nicotinic AntagonistsReceptors, Nicotinicacetylcholine-binding proteinbinding siteconotoxinsligand-binding domainnicotinic acetylcholine receptorsradioligand analysis

Identifiers

PMID30469507
PMCPMC6315749
OpenAlexW2900868023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.