ArticleBrain sciences2018
The Benefits of Closed-Loop Transcranial Alternating Current Stimulation on Subjective Sleep Quality.
Article in Brain sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effects of Transcranial Electrical Stimulation of the Brain on Sleep: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies-Related Issues and Future Directions.Sensors (Basel, Switzerland) · 2020Pooled it
- Cerebellar High Frequency Transcranial Pulsed Current Stimulation Increases Total Sleep Time in Chronic Insomnia: A Pilot Study.Research square · 2026Article
- Closed-loop transcranial alternating current stimulation (tACS) reduces cue reactivity and improves inhibitory control in methamphetamine use disorder with frequency and timing specificity.Molecular psychiatry · 2026Article
- Exploring the Effects of tACS Duration on Resting-State EEG: An Exploratory Within-Subject Study in Healthy Volunteers.Journal of medical systems · 2026Article
- Slow wave canonical activity deviation concept: Toward a slow wave-based EEG-fMRI reference map for health-associated network function.iScience · 2026Article
- Bayesian Temporal Prediction: A Robust Algorithm for Real-Time EEG Phase-Dependent Brain Stimulation.IEEE transactions on bio-medical engineering · 2026Article
- Monitoring Sleep Quality Through Low α-Band Activity in the Prefrontal Cortex Using a Portable Electroencephalogram Device: Longitudinal Study.Journal of medical Internet research · 2025Article
- Closed-Loop Auditory Stimulation (CLAS) During Sleep Augments Language and Discovery Learning.Brain sciences · 2024Article
- Can Neuromodulation Improve Sleep and Psychiatric Symptoms?Current psychiatry reports · 2024Review
- Closed-Loop Transcranial Electrical Neurostimulation for Sustained Attention Enhancement: A Pilot Study towards Personalized Intervention Strategies.Bioengineering (Basel, Switzerland) · 2024Article
- A classification-based generative approach to selective targeting of global slow oscillations during sleep.Frontiers in human neuroscience · 2024Article
- Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments.Translational psychiatry · 2023Review
- Closed-Loop tACS Delivered during Slow-Wave Sleep Reduces Retroactive Interference on a Paired-Associates Learning Task.Brain sciences · 2023Article
- Non-invasive brain stimulation and neuroenhancement.Clinical neurophysiology practice · 2022Review
- Toward Predicting Human Performance Outcomes From Wearable Technologies: A Computational Modeling Approach.Frontiers in physiology · 2021Article
- The Sleep Side of Aging and Alzheimer's Disease.Sleep medicine · 2021Review
- Noninvasive Brain Stimulation & Space Exploration: Opportunities and Challenges.Neuroscience and biobehavioral reviews · 2020Review
- Sleep, Noninvasive Brain Stimulation, and the Aging Brain: Challenges and Opportunities.Ageing research reviews · 2020Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundPoor sleep quality is a common complaint, affecting over one third of people in the United States. While sleep quality is thought to be related to slow-wave sleep (SWS), there has been little investigation to address whether modulating slow-wave oscillations (SWOs) that characterize SWS could impact sleep quality. Here we examined whether closed-loop transcranial alternating current stimulation (CL-tACS) applied during sleep impacts sleep quality and efficiency.
methodsCL-tACS was used in 21 participants delivered at the same frequency and in phase with endogenous SWOs during sleep. Sleep quality was assessed in the morning following either verum or sham control stimulation during sleep, with order counterbalanced within participants.
resultsHigher sleep quality and efficiency were found after verum stimulation nights compared to control. The largest effects on sleep quality were found immediately following an adaptation night in the laboratory for which sleep quality was reduced.
conclusionsApplying CL-tACS at the same frequency and phase as endogenous SWOs may offer a novel method to improve subjective sleep quality after a night with poor quality sleep. CL-tACS might be helpful for increasing sleep quality and efficiency in otherwise healthy people, and in patients with clinical disorders that involve sleep deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.