Evidence map›Paper›PMID 30469491›Full record

ReviewInternational journal of molecular sciences2018

Imaging and Molecular Mechanisms of Alzheimer's Disease: A Review.

Grazia Daniela Femminella, Tony Thayanandan, Valeria Calsolaro, Klara Komici, Giuseppe Rengo, Graziamaria Corbi, Nicola Ferrara

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. "Advances in biomarker discovery and diagnostics for alzheimer's disease".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Subjective Cognitive Decline Is Associated With Lower Baseline Cognition and Increased Rate of Cognitive Decline.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Grazia Daniela FemminellaNeurology Imaging Unit, Imperial College London, London W12 0NN, UK. g.femminella@imperial.ac.uk.
Tony ThayanandanImperial Memory Unit, Charing Cross Hospital, Imperial College London, London W6 8RF, UK. tony.thayanandan@nhs.net.
Valeria CalsolaroNeurology Imaging Unit, Imperial College London, London W12 0NN, UK. v.calsolaro@imperial.ac.uk.
Klara KomiciDepartment of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy. klara.komici@unimol.it.
Giuseppe RengoDepartment of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy. giuseppe.rengo@unina.it.
Graziamaria CorbiDepartment of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy. graziamaria.corbi@unimol.it.ORCID 0000-0002-3441-889X
Nicola FerraraDepartment of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy. nicola.ferrara@unina.it.ORCID 0000-0001-8200-4942

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is the most common form of dementia and is a significant burden for affected patients, carers, and health systems. Great advances have been made in understanding its pathophysiology, to a point that we are moving from a purely clinical diagnosis to a biological one based on the use of biomarkers. Among those, imaging biomarkers are invaluable in Alzheimer's, as they provide an in vivo window to the pathological processes occurring in Alzheimer's brain. While some imaging techniques are still under evaluation in the research setting, some have reached widespread clinical use. In this review, we provide an overview of the most commonly used imaging biomarkers in Alzheimer's disease, from molecular PET imaging to structural MRI, emphasising the concept that multimodal imaging would likely prove to be the optimal tool in the future of Alzheimer's research and clinical practice.

Indexed as

Alzheimer DiseaseAnimalsBlood-Brain BarrierHumansMagnetic Resonance ImagingPlaque, AmyloidPositron-Emission Tomographytau Proteinstau ProteinsAlzheimer’s diseasemagnetic resonance imaging (MRI)positron emission tomography (PET)

Identifiers

PMID30469491
PMCPMC6321449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.