ArticleSensors (Basel, Switzerland)2018
Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure.
Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Acoustic Bubble Sensing Techniques and Bioapplications.Biosensors · 2026Review
- Effects of Different Gas Cores on the Ambient Pressure Sensitivity of the Subharmonic Response of SonoVue.Ultrasound in medicine & biology · 2025Article
- Investigation Into the Subharmonic Response of Three Contrast Agents in Static and Dynamic Flow Environments Using a Commercially Available Diagnostic Ultrasound Scanner.Ultrasound in medicine & biology · 2024Article
- Advocating for the implementation of SonoVue microbubbles as pressure sensors: a call to action for clinical noninvasive pressure estimation.Hepatobiliary surgery and nutrition · 2024Article
- Acoustic response and ambient pressure sensitivity characterization of SonoVue for noninvasive pressure estimation.The Journal of the Acoustical Society of America · 2024Article
- [Experimental study on high-frequency subharmonic scattering characteristics of ultrasound contrast agent microbubbles under low ambient pressure].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Advances in Wireless, Batteryless, Implantable Electronics for Real-Time, Continuous Physiological Monitoring.Nano-micro letters · 2023Review
- Application of deep neural networks for inferring pressure in polymeric acoustic transponders/sensors.Machine learning with applications · 2023Article
- Ambient Pressure Sensitivity of the Subharmonic Response of Coated Microbubbles: Effects of Acoustic Excitation Parameters.Ultrasound in medicine & biology · 2023Article
- Noninvasive Estimation of Tumor Interstitial Fluid Pressure from Subharmonic Scattering of Ultrasound Contrast Microbubbles.Biosensors · 2023Article
- Material Properties, Dissolution and Time Evolution of PEGylated Lipid-Shelled Microbubbles: Effects of the Polyethylene Glycol Hydrophilic Chain Configurations.Ultrasound in medicine & biology · 2022Article
- Artificial intelligence and guidance of medicine in the bubble.Cell & bioscience · 2021Article
- [Experimental studies for noninvasive assessment of portal vein pressure based on contrast enhanced subharmonic sonographic imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Optimal Control of SonoVue Microbubbles to Estimate Hydrostatic Pressure.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Portal pressure monitoring-state-of-the-art and future perspective.Annals of translational medicine · 2019Review
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Authors and funding
3 authors.
Funding
Abstract
Microbubbles are considered a promising tool for noninvasive estimation of local blood pressure. It is reported that the subharmonic scattering amplitude of microbubbles decreases by 9 to 12 dB when immersed in the media under an ambient pressure variation from 0 to 180 mmHg. However, the pressure sensitivity still needs to be improved to satisfy clinical diagnostic requirements. Here, we investigated the effects of acoustic parameters on the pressure sensitivity of microbubbles through measuring the acoustic attenuation and scattering properties of commercially available SonoVue microbubbles. Our results showed that the first harmonic, subharmonic, and ultraharmonic amplitudes of microbubbles were reduced by 6.6 dB, 10.9 dB, and 9.3 dB at 0.225 mechanical index (MI), 4.6 dB, 19.8 dB, and 12.3 dB at 0.25 MI, and 18.5 dB, 17.6 dB, and 12.6 dB at 0.3 MI, respectively, when the ambient pressure increased from 0 to 180 mmHg. Our finding revealed that a moderate MI (0.25⁻0.4) exciting microbubbles could significantly improve their sensitivities to detect ambient pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.