ArticleInternational journal of molecular sciences2018
Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus-The Effect on Adverse Pregnancy Outcomes.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal hyperuricemia and adverse maternal-fetal outcomes: a systematic review and meta-analysis of observational studies.Frontiers in medicine · 2026Pooled it
- Maternal Electronic Cigarette Inhalation Exposure During Gestation: Impacts on Prolactin and Xanthine Oxidase.Cardiovascular toxicology · 2025Article
- Biochemical Markers in the Prediction of Pregnancy Outcome in Gestational Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2024Article
- Association of maternal serum uric acid levels with LBW/SGA: a large retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- New perspective on first-trimester serum uric acid level in predicting the risk of gestational diabetes mellitus.Scientific reports · 2024Article
- Elevated uric acid in gestational diabetes and its risk on pregnancy outcomes.SAGE open medicine · 2024Article
- Does the Micronutrient Molybdenum Have a Role in Gestational Complications and Placental Health?Nutrients · 2023Review
- Pre-pregnancy body mass index combined with peripheral blood PLGF, DCN, LDH, and UA in a risk prediction model for pre-eclampsia.Frontiers in endocrinology · 2023Article
- Role of Uric Acid Levels in the Development of Gestational Diabetes Mellitus: A Review.Cureus · 2022Review
- Predictive Gestational Diabetes Biomarkers With Sustained Alterations Throughout Pregnancy.Journal of the Endocrine Society · 2022Review
- Characterizing and Evaluating Diurnal Salivary Uric Acid Across Pregnancy Among Healthy Women.Frontiers in endocrinology · 2022Article
- Metabolites involved in purine degradation, insulin resistance, and fatty acid oxidation are associated with prediction of Gestational diabetes in plasma.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Uric acid participating in female reproductive disorders: a review.Reproductive biology and endocrinology : RB&E · 2021Review
- High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.
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