ArticleInternational journal of environmental research and public health2018
Increased Risk of Ulcerative Colitis in Patients with Periodontal Disease: A Nationwide Population-Based Cohort Study.
Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Grading the evidence for the association between periodontal disease and chronic non-communicable diseases: an umbrella review of meta-analyses of observational studies.BMC oral health · 2026Pooled it
- Patients with inflammatory bowel disease have a higher chance of developing periodontitis: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- The Association between Periodontitis and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.BioMed research international · 2021Pooled it
- Elevated periodontal disease risk in ulcerative colitis patients: evidence from a comparative case-control study.Odontology · 2026Article
- The oral‒gut axis in periodontal disease: a systematic review of the associated human evidence of its mechanisms and implications for patient care.Journal of oral microbiology · 2026Review
- Associations between oral health problems and inflammatory bowel disease: evidence from prospective cohort study.Frontiers in immunology · 2026Article
- Bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease: A systematic review and meta-analysis.The Japanese dental science review · 2025Review
- Periodontitis-associated Fusobacterium nucleatum promotes ulcerative colitis by ferroptosis-mediated gut barrier disruption.NPJ biofilms and microbiomes · 2025Article
- Oral-gut axis in inflammation: periodontitis exacerbates ulcerative colitis via microbial dysbiosis and barrier disruption.BMC oral health · 2025Article
- Shared immune-inflammatory mechanisms between ulcerative colitis and periodontitis: a multi-omics analysis.Frontiers in immunology · 2025Article
- Applications and interventions of polymers and nanomaterials in alveolar bone regeneration and tooth dentistry.RSC advances · 2024Review
- Causal Association Analysis of Periodontitis and Inflammatory Bowel Disease: A Bidirectional Mendelian Randomization Study.Inflammatory bowel diseases · 2024Article
- Linking Periodontitis with Inflammatory Bowel Disease through the Oral-Gut Axis: The Potential Role ofBiomedicines · 2024Review
- Review
- Periodontal bacteria influence systemic diseases through the gut microbiota.Frontiers in cellular and infection microbiology · 2024Review
- Dental Caries, Dental Erosion and Periodontal Disease in Children with Inflammatory Bowel Disease.International journal of medical sciences · 2023Article
- The effect of the "Oral-Gut" axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations.Frontiers in cellular and infection microbiology · 2023Review
- Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease: evidence from transcriptome data.Gastroenterology report · 2023Article
- Pathogenic associations between oral and gastrointestinal diseases.Trends in molecular medicine · 2022Review
- Periodontitis prevalence in patients with ulcerative colitis and Crohn's disease - PPCC: A case-control study.Journal of clinical periodontology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both periodontal disease (PD) and inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are important diseases of the alimentary tract. Microbiome and immune-mediated inflammatory processes play important roles in these diseases. An association between PD and IBD may exist. This study investigated the risk of IBD in patients with PD. This study used data from the National Health Insurance Research Database of Taiwan from 1996 to 2013. A total of 27,041 patients with PD were enrolled as a study group, and 108,149 patients without PD were selected as the control group after matching by gender, age, insured region, urbanization, and income with a 1:4 ratio. Cox proportional hazards regression was used to calculate the risk of IBD. Of the 135,190 participants enrolled in this study, 5392 (4%) with newly diagnosed IBD were identified. The overall incidence of subsequent IBD was similar in both groups (3.8% vs. 4%, adjusted hazard ratio (aHR) = 1.01, 95% confidence interval (CI): 0.94⁻1.08). However, an increased risk of UC in the PD group was found after adjusting confounding factors (aHR: 1.56, 95% CI: 1.13⁻2.15;
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.