Evidence map›Paper›PMID 30469358›Full record

ArticleInternational journal of molecular sciences2018

Interactions Between Spermine-Derivatized Tentacle Porphyrins and The Human Telomeric DNA G-Quadruplex.

Navin C Sabharwal, Jessica Chen, Joo Hyun June Lee, Chiara M A Gangemi, Alessandro D'Urso, Liliya A Yatsunyk

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Molecules (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Navin C SabharwalDepartment of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA. navin.sabharwal.424@gmail.com.
Jessica ChenDepartment of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA. ymchen.017@gmail.com.
Joo Hyun June LeeDepartment of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA. jlee2143@gmail.com.
Chiara M A GangemiDepartment of Chemical Science, University of Catania, 95125 Catania, Italy. gangemichiara@unict.it.
Alessandro D'UrsoDepartment of Chemical Science, University of Catania, 95125 Catania, Italy. adurso@unict.it.ORCID 0000-0002-0255-1792
Liliya A YatsunykDepartment of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA. lyatsun1@swarthmore.edu.ORCID 0000-0003-3946-0939
Swarthmore College · USUniversity of Catania · IT

Funding

Deciphering the structure and dynamics of quadruplex DNA and DNA-ligand complexesR15CA208676 · NCI · SWARTHMORE COLLEGE · PI YATSUNYK, LILIYA A · 2017 to 2017
$411k
Benjamin Franklin Travel GrantCamille and Henry Dreyfus Foundation Teacher-Scholar AwardHoward Hughes Medical Institute undergraduate research fellowshipNational Institutes of Health 1R15CA208676-01A1NCI NIH HHS R15 CA208676The University of Catania "Piano della Ricerca di Ateneo 2016-2018"
6 · The paper itself

Abstract

G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures implicated in aging and human diseases, notably cancers. Because stabilization of GQs at telomeres and oncogene promoters may prevent cancer, there is an interest in developing small molecules that selectively target GQs. Herein, we investigate the interactions of

Indexed as

G-QuadruplexesDNAHumansIntercalating AgentsPorphyrinsSpermineTelomereDNAIntercalating AgentsPorphyrinsSperminetetrakis(4-(carboxymethyleneoxy)phenyl)porphyrinanti-cancer therapyend-stackingG-quadruplextentacle porphyrinsZn(II) porphyrin

Identifiers

PMID30469358
PMCPMC6274827
OpenAlexW2900704891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.