Evidence map›Paper›PMID 30469344›Full record

ReviewMolecules (Basel, Switzerland)2018

A Review on Electroporation-Based Intracellular Delivery.

Junfeng Shi, Yifan Ma, Jing Zhu, Yuanxin Chen, Yating Sun, Yicheng Yao, Zhaogang Yang, Jing Xie

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 248 citations in OpenAlex.

  1. Electroporation for High-Efficiency Delivery of CRISPR to Hematopoietic Cells.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. [Coupling characteristics of cellular electroporation and electrodeformation based on dynamic Young's modulus: influence of membrane thickness].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  3. Developing Optogenetic Approaches to Study CaCold Spring Harbor perspectives in biology · 2026
    Review
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65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Junfeng ShiDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA. shi.356@buckeyemail.osu.edu.
Yifan MaDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA. ma.1711@buckeyemail.osu.edu.
Jing ZhuCollege of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. syusejing@gmail.com.
Yuanxin ChenDepartment of Neurosurgery, Mayo Clinic College of Medicine, Jacksonville, FL 33573, USA. chen.yuanxin@mayo.edu.
Yating SunSchool of Life Sciences, Jilin University, Changchun 130012, China. sunyt16@jlu.edu.cn.
Yicheng YaoSchool of Life Sciences, Jilin University, Changchun 130012, China. cqupharm@163.com.
Zhaogang YangDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA. yang.1140@osu.edu.
Jing XieSchool of Life Sciences, Jilin University, Changchun 130012, China. xiejing@jlu.edu.cn.
The Ohio State University · USJilin University · CNJacksonville College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular delivery is a critical step in biological discoveries and has been widely utilized in biomedical research. A variety of molecular tools have been developed for cell-based gene therapies, including FDA approved CAR-T immunotherapy, iPSC, cell reprogramming and gene editing. Despite the inspiring results of these applications, intracellular delivery of foreign molecules including nucleic acids and proteins remains challenging. Efficient yet non-invasive delivery of biomolecules in a high-throughput manner has thus long fascinates the scientific community. As one of the most popular non-viral technologies for cell transfection, electroporation has gone through enormous development with the assist of nanotechnology and microfabrication. Emergence of miniatured electroporation system brought up many merits over the weakness of traditional electroporation system, including precise dose control and high cell viability. These new generation of electroporation systems are of considerable importance to expand the biological applications of intracellular delivery, bypassing the potential safety issue of viral vectors. In this review, we will go over the recent progresses in the electroporation-based intracellular delivery and several potential applications of cutting-edge research on the miniatured electroporation, including gene therapy, cellular reprogramming and intracellular probe.

Indexed as

AnimalsCell SurvivalCell TransplantationDrug Delivery SystemsElectroporationGenetic TherapyHumansMicrotechnologyNanotechnologyNucleic AcidsProteinsNucleic AcidsProteinselectroporationintracellular deliverymicrofabricationminiatured electroporation

Identifiers

PMID30469344
PMCPMC6278265
OpenAlexW2901575037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.