Evidence map›Paper›PMID 30469095›Full record

ArticleDrug and alcohol dependence2019

Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys.

Melis Odabas-Geldiay, Hannah Shields, Lais F Berro, Kenner C Rice, Leonard L Howell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Guanosine ameliorates positive symptoms of schizophreniaAmerican journal of translational research · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Melis Odabas-GeldiayYerkes National Primate Research Center, Emory University, 954 Gatewood Road N.E., Atlanta, GA, USA.
Hannah ShieldsYerkes National Primate Research Center, Emory University, 954 Gatewood Road N.E., Atlanta, GA, USA.
Lais F BerroYerkes National Primate Research Center, Emory University, 954 Gatewood Road N.E., Atlanta, GA, USA; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, USA.
Kenner C RiceDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institutes of Drug Abuse, Rockville, MD, USA.
Leonard L HowellYerkes National Primate Research Center, Emory University, 954 Gatewood Road N.E., Atlanta, GA, USA; Department of Psychiatry and Behavioral Science, Emory School of Medicine, Emory University, Atlanta, GA, USA. Electronic address: lhowell@emory.edu.
Emory University Hospital · USEmory University · USNational Institute on Drug Abuse · USUniversity of Mississippi Medical Center · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
PET IMAGING AND COCAINE NEUROPHARMACOLOGY IN MONKEYSR01DA010344 · NIDA · EMORY UNIVERSITY · PI HOWELL, LEONARD L · 1997 to 2006
$2.7M
Neuropharmacology of Abused Stimulants in Nonhuman PrimatesK05DA031246 · NIDA · EMORY UNIVERSITY · PI HOWELL, LEONARD L · 2012 to 2016
$619k
NIDA NIH HHS K05 DA031246NIDA NIH HHS R01 DA010344NIH HHS P51 OD011132
6 · The paper itself

Abstract

backgroundSerotonin 5-HT

methodsIn the present study, we investigated the effects of the selective 5HT

resultsPretreatment with M100907 (0.03-0.3 mg/kg, i.m.) dose-dependently attenuated methamphetamine self-administration, with the highest dose significantly decreasing response rates compared to vehicle. Combined administration of ineffective doses of M100907 and WAY 163,909 had no effects on methamphetamine self-administration.

conclusionsOur study indicates that acute selective 5-HT

Indexed as

AnimalsAzepinesBehavior, AddictiveCentral Nervous System StimulantsDose-Response Relationship, DrugDrug Therapy, CombinationFemaleFluorobenzenesIndolesMacaca mulattaMaleMethamphetaminePiperidinesReinforcement, PsychologySelf AdministrationSerotonin 5-HT2 Receptor Agonists1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indoleAzepinesCentral Nervous System StimulantsFluorobenzenesIndolesMethamphetaminePiperidinesSerotonin 5-HT2 Receptor AgonistsSerotonin 5-HT2 Receptor AntagonistsSerotonin AntagonistsvolinanserinMethamphetamineReinforcementRhesus macaquesSelf-administrationSerotonin

Identifiers

PMID30469095
PMCPMC6312465
OpenAlexW2901296188

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.