Evidence map›Paper›PMID 30468945›Full record

ArticleEpilepsy research2019

Beyond depression: The impact of executive functioning on quality of life in patients with temporal lobe epilepsy.

Tobin Ehrlich, Anny Reyes, Brianna M Paul, Vedang Uttarwar, Stephen Hartman, Kushagra Mathur, Yu-Hsuan A Chang, Manu Hegde, Jerry J Shih, Carrie R McDonald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Determinants of health-related quality of life of patients with focal epilepsy: A systematic literature review.Epileptic disorders : international epilepsy journal with videotape · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Tobin EhrlichPalo Alto University, 1971 Arastradero Drive, Palo Alto, CA 94304, USA.
Anny ReyesSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Brianna M PaulUCSF Comprehensive Epilepsy Center, San Francisco, CA, USA; Department of Neurology, University of California - San Francisco, San Francisco, CA, USA.
Vedang UttarwarCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Stephen HartmanCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Kushagra MathurCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Yu-Hsuan A ChangCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA.
Manu HegdeUCSF Comprehensive Epilepsy Center, San Francisco, CA, USA.
Jerry J ShihUCSD Comphrensive Epilepsy Center, San Diego, CA, USA.
Carrie R McDonaldSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA; UCSD Comphrensive Epilepsy Center, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA. Electronic address: camcdonald@ucsd.edu.
University of California San Diego · USSan Diego State University · USPalo Alto University · USUniversity of California, San Francisco · USUniversity of California System · US

Funding

Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
NINDS NIH HHS R01 NS065838
6 · The paper itself

Abstract

objectiveIndividuals with temporal lobe epilepsy (TLE) often experience diminished quality of life (QoL). Although comorbid depression is one of the most recognized predictors of poor QoL in TLE, impairments in verbal memory (VM) and executive functioning (EF), have also been identified as risk factors, independent of other biological and psychosocial factors. In this study, we examine the contribution of depression, VM, and EF to QoL in 52 well-characterized medically-refractory TLE patients.

methodsQuality of life was assessed with the Quality of Life in Epilepsy (QOLIE-31) questionnaire and depression symptomatology was evaluated with the Beck Depression Inventory-II (BDI-II). Tests of VM included the California Verbal Learning Test-Second Edition and the Wechsler Memory Scale-Third Edition, Logical Memory and Verbal Paired Associates subtests. Tests of EF included the D-KEFS Category Switching and Color Word Interference Tests, and the Trail Making Test. Using these measures, a principal component (PC) was derived for VM and for EF. Hierarchical multiple linear regression analysis was used to evaluate the unique contributions of BDI-II Score, VM PC, and EF PC to the QOLIE-31 Total Score, while controlling for important clinical and demographic variables. Post-hoc analyses were also performed to examine the contribution of each variable to specific QOLIE subscales.

resultsOf the clinical variables, only number of antiepileptic drugs contributed to QOLIE scores. As expected, severity of depressive symptoms was the most significant predictor of QOLIE Total Score, explaining 43.4% of the variance in total QoL. The VM PC did not contribute to the QOLIE Total Score. Rather, our EF PC emerged as an important predictor of QoL, explaining an additional 5% of the variance, after controlling for clinical variables, depression severity, and VM performance. SIGNIFICANCE: These findings suggest that a combination of clinical, affective, and cognitive factors influence QoL in patients with TLE. Designing interventions with careful attention to depression and EF may be needed to optimize QoL in patients with refractory TLE and potentially other epilepsy syndromes.

Indexed as

AdultCognition DisordersDepressionEpilepsy, Temporal LobeExecutive FunctionFemaleHumansLinear ModelsMaleMiddle AgedPrincipal Component AnalysisQuality of LifeVerbal LearningDepressionEpilepsyExecutive functioningQuality of lifeTemporal lobe epilepsyVerbal memory

Identifiers

PMID30468945
PMCPMC6326842
OpenAlexW2900672458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.