Evidence map›Paper›PMID 30468888›Full record

ArticleNeuroscience letters2019

Further observations on cardiac modulation of thoracic motoneuron discharges.

P A Kirkwood, J R Romaniuk, K E Kowalski

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

P A KirkwoodUCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK. Electronic address: peter.kirkwood@ucl.ac.uk.
J R RomaniukResearch Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
K E KowalskiResearch Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA; Department of Medicine and MetroHealth Research Institute, Case Western Reserve University, Cleveland, OH, USA.
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · USNational Hospital for Neurology and Neurosurgery · GB

Funding

High Frequency Spinal Cord Stimulation to Restore CoughI01RX001488 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI KOWALSKI, KRZYSZTOF E · 2015 to 2019
–
RRD VA I01 RX001488Wellcome TrustWellcome Trust 038027/Z/93/Z/1.5
6 · The paper itself

Abstract

Previous analyses of recordings of alpha motoneuron discharges from branches of the intercostal and abdominal nerves in anesthetized cats under neuromuscular blockade demonstrated modulation with the cardiac cycle. This modulation was interpreted as evidence that thoracic somatosensory afferents, most likely muscle spindles, provide a signal to the CNS that could contribute to cardiac interoception. Here, two aspects of these observations have been extended. First, new measurements of thoracic and abdominal EMG activity in spontaneously breathing dogs show that a very similar modulation exists in these rather different circumstances. Second, further analysis of the cat recordings shows that cardiac modulation of the discharges of bulbospinal neurons that transmit the expiratory drive to thoracic motoneurons is weak and of an inappropriate time-course to be a contributor to the effect seen in the motoneurons.

Indexed as

ExhalationAbdominal MusclesAnimalsCatsDogsElectric StimulationElectromyographyIntercostal MusclesMaleMotor NeuronsSpinal CordAbdominal motoneuronsCardiac modulationExpiratory bulbospinal neuronsIntercostal motoneuronsInteroceptionThoracic spinal cord

Identifiers

PMID30468888
PMCPMC9373061
OpenAlexW2900904866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.