Evidence map›Paper›PMID 30468693›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2019

MRI Outperforms [18F]AV-1451 PET as a Longitudinal Biomarker in Progressive Supranuclear Palsy.

Jennifer L Whitwell, Nirubol Tosakulwong, Christopher G Schwarz, Hugo Botha, Matthew L Senjem, Anthony J Spychalla, J Eric Ahlskog, David S Knopman, Ronald C Petersen, Clifford R Jack and 2 more

Open access · greenAbstract read
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Subtracting First Principal Component May Improve 4R Tau Detectability on [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
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  12. Article
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  14. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Observational
  15. Imaging pathological tau in atypical parkinsonisms: A review.Clinical parkinsonism & related disorders · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Gray and White Matter Correlates of Dysphagia in Progressive Supranuclear Palsy.Movement disorders : official journal of the Movement Disorder Society · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Nirubol TosakulwongDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Hugo BothaDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Matthew L SenjemDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Anthony J SpychallaDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
J Eric AhlskogDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy SyndromesR01NS089757 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2015 to 2024
$5.6M
NIA NIH HHS R01 AG034676NIA NIH HHS R01-AG34676NIA NIH HHS U01 AG006786NIA NIH HHS U01-AG006786NINDS NIH HHS R01 NS089757NINDS NIH HHS R01-NS89757
6 · The paper itself

Abstract

backgroundElevated uptake of the [

methodsSixteen subjects with PSP underwent 2 serial [

resultsRate of midbrain atrophy was significantly increased in PSP compared with controls. [

conclusions[

Indexed as

Magnetic Resonance ImagingAgedAged, 80 and overBiomarkersCarbolinesCerebral CortexFemaleGlobus PallidusHumansMaleMiddle AgedParkinson DiseaseSupranuclear Palsy, Progressivetau Proteins7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleBiomarkersCarbolinestau Proteinspositron emission tomographyratesRichardson's syndromeserialtau

Identifiers

PMID30468693
PMCPMC6361527
OpenAlexW2901938238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.