Evidence map›Paper›PMID 30468306›Full record

ArticleChemical biology & drug design2019

A rapid method for estimation of the efficacy of potential antimicrobials in humans and animals by agar diffusion assay.

Elena G Salina, Sean Ekins, Vadim A Makarov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical biology & drug design, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Elena G SalinaBach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.
Sean EkinsCollaborations Pharmaceuticals, Inc., Raleigh, North Carolina.
Vadim A MakarovBach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0001-8746-2694
A N Bach Institute of Biochemistry · RUCollaborations Pharmaceuticals (United States) · US

Funding

New generation of non-nucleoside RT HIV inhibitors avoiding HIV-associated neurocognitive disordersR01NS102164 · NINDS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN, NELSON, JULIE AE · 2017 to 2019
$587k
NINDS NIH HHS R01 NS102164
6 · The paper itself

Abstract

Drug resistance continues to challenge traditional antimicrobial drugs and limit their clinical utility. This requires us to continue our search for new drug candidates with novel mechanisms of action against infectious diseases. We now describe a simple agar diffusion assay, which can be used as a general method for the rapid detection of antimicrobial activity of drug candidates in animal or human blood plasma for the ultimate prediction of the efficacy of potential drugs prior to clinical trials. We present an example for a clinical candidate against Mycobacterium tuberculosis.

Indexed as

AgarAnimalsAntitubercular AgentsClinical Trials, Phase I as TopicHumansImmunodiffusionMicrobial Sensitivity TestsMycobacterium smegmatisPiperazinesThiazinesAgarAntitubercular AgentsmacozinonePiperazinesThiazinesagar diffusion assayantimicrobial activityclinical trialsdrug candidatemacozinoneTuberculosis

Identifiers

PMID30468306
PMCPMC6533168
OpenAlexW2901062373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.