Evidence map›Paper›PMID 30467975›Full record

ArticleJournal of cellular and molecular medicine2019

ADIPOQ, KCNJ11 and TCF7L2 polymorphisms in type 2 diabetes in Kyrgyz population: A case-control study.

Jainagul Isakova, Elnura Talaibekova, Denis Vinnikov, Iskender Saadanov, Nazira Aldasheva

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Journal of diabetes research · 2020
    Pooled it
  4. Pooled it
  5. Frontiers in endocrinology · 2019
    Pooled it
  6. Association ofBioscience reports · 2019
    Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Identifying the association between single nucleotide polymorphisms inInternational journal of medical sciences · 2020
    Observational
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Jainagul IsakovaInstitute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan.ORCID 0000-0002-3681-6939
Elnura TalaibekovaInstitute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan.
Denis VinnikovInstitute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan.
Iskender SaadanovInstitute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan.
Nazira AldashevaInstitute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan.
Al-Farabi Kazakh National University · KZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to ascertain the polymorphic markers profile of ADIPOQ, KCNJ11 and TCF7L2 genes in Kyrgyz population and to analyze the association of polymorphic markers and combinations of ADIPOQ gene's G276T locus, KCNJ11 gene's Glu23Lys locus and TCF7L2 gene's VS3C>T locus with type two diabetes (T2D) in Kyrgyz population. In this case-control study, 114 T2D patients 109 non-diabetic participants were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Two individual polymorphisms (ADIPOQ rs1501299, KCNJ11 rs5219) were found to be associated with T2D. We found two (Lys23Lys/CC and Glu23Lys/CT) of the overall nine combinations, which were more prevalent in T2D group compared to controls (χ

Indexed as

AdiponectinAllelesDiabetes Mellitus, Type 2FemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansKcnj11 ChannelKyrgyzstanMalePolymorphism, Single NucleotidePotassium Channels, Inwardly RectifyingTranscription Factor 7-Like 2 ProteinAdiponectinADIPOQ protein, humanKcnj11 ChannelPotassium Channels, Inwardly RectifyingTCF7L2 protein, humanTranscription Factor 7-Like 2 ProteinADIPOQgeneKCNJ11polymorphismTCF7L2type 2 diabetes

Identifiers

PMID30467975
PMCPMC6349214
OpenAlexW2900746613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.