ArticleThe Laryngoscope2019
Acute inflammatory response to contrast agent aspiration and its mechanisms in the rat lung.
Article in The Laryngoscope, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- ESSD-ESGAR best practice position statements on the technical performance of videofluoroscopic swallowing studies in adult patients with swallowing disorders.European radiology · 2025Guideline
- Article
- Inadvertently Displayed Trajectory of Type C Oesophageal Atresia during a Contrast Study.African journal of paediatric surgery : AJPS · 2024Article
- Validation of Earphone-Type Sensors for Non-Invasive and Objective Swallowing Function Assessment.Sensors (Basel, Switzerland) · 2022Article
- Risk Factors for Aspiration Pneumonia After Receiving Liquid-Thickening Recommendations.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2022Review
- Oral SARS-CoV-2 Inoculation Causes Nasal Viral Infection Leading to Olfactory Bulb Infection: An Experimental Study.Frontiers in cellular and infection microbiology · 2022Article
- The Landscape of Videofluoroscopy in the UK: A Web-Based Survey.Dysphagia · 2021Article
- Chronic inflammatory response in the rat lung to commonly used contrast agents for videofluoroscopy.Laryngoscope investigative otolaryngology · 2019Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectives/hypothesisContrast agent (CA) aspiration is an established complication of upper gastrointestinal and videofluoroscopic swallow studies. The underlying molecular biological mechanisms of acute response to CA aspiration in the respiratory organs remain unclear. The aims of this study were to elucidate the histological and biological influences of three kinds of CAs on the lung and to clarify the differences in acute responses. STUDY
designAnimal model.
methodsEight-week-old male Sprague Dawley rats were divided into five groups (n = 6 in each group). Three groups underwent tracheal instillation of one of three different CAs: barium (Ba) sulfate, nonionic contrast agents (NICAs), and ionic contrast agents (ICAs). A control group was instilled with saline and a sham group was instilled with air. All animals were euthanized on day 2 after treatment and histological and gene analysis was performed.
resultsNo animal died after CA or control/sham aspiration. Ba caused severe histopathologic changes and more prominent inflammatory cell infiltration in the lungs compared with the two other iodinated contrast agents. Increases in expressions of inflammatory cytokines (tumor necrosis factor [Tnf], interleukin-1β [Il1b], and interferon-γ [Ifng]) were observed in Ba aspiration rats, and upregulation of Il1b was seen in ICA aspiration rats. NICA did not cause obvious histologic changes or expressions of inflammatory cytokines and fibrosis-related genes in the lungs.
conclusionsBa caused significantly more acute lung inflammation in a rodent model than did ioinic and nonionic iodinated CAs. Nonionic contrast did not cause any discernible inflammatory response in the lungs, suggesting that it may be the safest contrast for videofluoroscopic swallow studies. LEVEL OF EVIDENCE: NA Laryngoscope, 129:1533-1538, 2019.
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